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A subgroup of these patients with multisystem involvement showed a significantly decreased lymphocyte response to both Con A and PWM when compared to normal controls. However those PSS patients with myositis, although having multisystem involvement, had normal lymphocyte response to all three mitogens. PHA\u2010P stimulation was normal in all PSS patients. Antinuclear antibodies, elevated sedimentation rates, and positive latex fixation were noted only in the multisystem disease group with abnormal lymphocyte function.<\/jats:p>","DOI":"10.1002\/art.1780190507","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:40:11Z","timestamp":1171474811000},"page":"875-882","source":"Crossref","is-referenced-by-count":28,"title":["Lymphocyte response to mitogens in progressive systemic sclerosis"],"prefix":"10.1002","volume":"19","author":[{"given":"Noel B.","family":"Salem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane H.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.31.2.126"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb02523.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180308"},{"key":"e_1_2_1_5_2","first-page":"336","article-title":"Circulating T and B lymphocytes in progressive systemic sclerosis","volume":"2","author":"de Jesus DG","year":"1975","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180303"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90639-7"},{"key":"e_1_2_1_8_2","first-page":"152","article-title":"In vivo and in vitro study of cell mediated immunity (CMI) during the onset of systemic lupus erythematosus (SLE)","volume":"14","author":"Bitter T","year":"1971","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150406"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780100105"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107085"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.29.3.220"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170504"},{"issue":"97","key":"e_1_2_1_14_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(74)90027-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12681110"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170418"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_19_2","first-page":"828","article-title":"Mixed connective tissue disease","volume":"25","author":"Sharp GC","year":"1975","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_20_2","first-page":"83","article-title":"Classification and pathogenesis of scleroderma","volume":"46","author":"Winkelmann RK","year":"1971","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.4049\/jimmunol.110.2.362","article-title":"Functional heterogeneity of murine lymphoid cells","volume":"110","author":"Stobo JO","year":"1973","journal-title":"J Immunol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4049\/jimmunol.113.4.1113","article-title":"Immunologic functions of isolated human lymphocyte subpopulations","volume":"113","author":"Chess L","year":"1974","journal-title":"J Immunol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.4.1021"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160504"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780120602"}],"container-title":["Arthritis &amp; 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