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In less severely damaged chondrocytes, these granules and vesicles appeared to be formed by pinching off of the cytoplasmic processes or by budding from the processes. Calcification of the granules was minimal. In severely damaged chondrocytes, an admixture of these granules and cytoplasmic organelles occurred. It is speculated that many of these dense granules are lysosomal in nature and that they may produce inflammation and reduce the proteoglycan content of cartilage.<\/jats:p>","DOI":"10.1002\/art.1780200116","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:06:42Z","timestamp":1171476402000},"page":"91-99","source":"Crossref","is-referenced-by-count":17,"title":["Relapsing polychondritis"],"prefix":"10.1002","volume":"20","author":[{"given":"Ken","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90023-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2106\/00004623-197254060-00011","article-title":"Relapsing polychondritis: an electron microscopic study of synovium and articular cartilage","volume":"54","author":"Mitchell N","year":"1972","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)93341-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180614"},{"key":"e_1_2_1_6_2","first-page":"363","article-title":"Relapsing polychondritis","volume":"41","author":"Hughes RAC","year":"1972","journal-title":"Q J Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1970.00770040258017"},{"key":"e_1_2_1_8_2","first-page":"27","article-title":"Relapsing polychondritis associated with ulcerative colitis","volume":"39","author":"Reefe WE","year":"1970","journal-title":"Med Ann DC"},{"key":"e_1_2_1_9_2","first-page":"93","article-title":"Polychondropathia","volume":"6","author":"Jaksch\u2010Wartenhorst R","year":"1923","journal-title":"Wein Arch Innere Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(75)90022-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.108.4.507"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150210"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.39.1.43"},{"key":"e_1_2_1_15_2","first-page":"135","article-title":"Analysis of matrix vesicles and their role in the calcification of epiphyseal cartilage","volume":"35","author":"Ali SY","year":"1976","journal-title":"Fed Proc"},{"key":"e_1_2_1_16_2","first-page":"148","article-title":"Calcification of rachitic cartilage to study matrix vesicle function","volume":"35","author":"Anderson HC","year":"1976","journal-title":"Fed Proc"},{"key":"e_1_2_1_17_2","first-page":"239","volume-title":"A Textbook of Histology","author":"Bloom W","year":"1975"},{"key":"e_1_2_1_18_2","first-page":"1201","volume-title":"Studies on the interactions between glycosaminoglycans and fibrillar collagen, Chemistry and Molecular Biology of the Intercellular Matrix. 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