{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:30:24Z","timestamp":1774528224439,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":10493,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With initial hopes of establishing a diagnostic test for juvenile rheumatoid arthritis (JRA), five types of immunoadsorbents were used to search for occult antiglobulins in sera from children. The immunoadsorbents included glutaraldehyde\u2010aggregated globulin, heat\u2010 and glutaraldehyde\u2010aggregated globulin, Affi\u2010Gel\u2010bound globulin, Sepharose\u2010bound globulin, and bromoacetyl cellulose\u2010bound globulin. The glutaraldehyde\u2010aggregated immunoadsorbents retained nonspecific protein. The Affi\u2010Gel, Sepharose, and bromoacetyl cellulose adsorbents were effective and specific, but the Affi\u2010Gel and bromoacetyl cellulose were impractical for routine use. Sepharose\u2010bound globulin was selected for use in a survey of 52 patients with JRA and 8 normal children. Materials resembling occult antiglobulins, measured as acid elutable protein, were found in normal children as well as in children with JRA. Only a small proportion of children with JRA had statistically elevated levels of such occult anti\u2010globulins. The protein adsorbed to Sepharose\u2010bound globulin consisted of IgM, IgG, and IgA, and had latex fixation activity in 2 of 5 tested sera from normal children and in 27 of 52 sera from children with JRA. Thus the presence of antiglobulins per se is not diagnostically helpful in distinguishing children with JRA.<\/jats:p>","DOI":"10.1002\/art.1780200214","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:05:24Z","timestamp":1171476324000},"page":"729-735","source":"Crossref","is-referenced-by-count":20,"title":["Antiglobulins in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"20","author":[{"suffix":"III","given":"John J.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Olds\u2010Arroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.28.4.424"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140603"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.3.255"},{"key":"e_1_2_1_5_2","first-page":"91","article-title":"Immunological properties of isolated IgG and IgM anti\u2010gamma\u2010globulins (rheumatoid factors)","volume":"17","author":"Bianco NE","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","first-page":"712","article-title":"Criteria for the classification of juvenile rheumatoid arthritis","volume":"23","author":"Brewer EJ","year":"1973","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1542\/peds.50.6.940","article-title":"Juvenile rheumatoid arthritis: a review","volume":"50","author":"Schaller J","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90178-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00807a031"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(67)90192-9"},{"key":"e_1_2_1_11_2","first-page":"125","article-title":"Human anti\u2010\u03b3\u2010globulin antibodies specific for \u03b3 G heavy chain subclasses","volume":"19","author":"Natvig JB","year":"1970","journal-title":"Immunology"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4049\/jimmunol.115.2.365","article-title":"The molecular basis of self\u2010association of IgG\u2010rheumatoid factors","volume":"115","author":"Pope RM","year":"1975","journal-title":"J Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780200214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780200214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T13:39:45Z","timestamp":1700746785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780200214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["10.1002\/art.1780200214"],"URL":"https:\/\/doi.org\/10.1002\/art.1780200214","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]}}}