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Serum was from patients with systemic lupus erythematosus known to have antibodies to soluble nuclear ribonucleoprotein (RNP) or to a soluble nuclear non\u2010nucleic acid protein (Sm). Amounts of antibody that was predominantly IgG ranged from 0.2 to 8 mg\/ml of patients' serum, and in some cases accounted for over 20% of the total serum IgG. Results demonstrate that some patients respond to the disease by producing large amounts of a specific antibody, and that these antibodies can contribute significantly to hypergammaglobulinemia.<\/jats:p>","DOI":"10.1002\/art.1780200310","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:03:44Z","timestamp":1171476224000},"page":"819-824","source":"Crossref","is-referenced-by-count":64,"title":["Quantitation of precipitating antibodies to certain soluble nuclear antigens in sle"],"prefix":"10.1002","volume":"20","author":[{"given":"Peter J.","family":"Maddison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"202","article-title":"Immunological studies of systemic lupus erythematosus. 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