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Active SLE patients had significantly more plaque\u2010forming cells in their peripheral blood to a total of five chemical determinants than did patients with inactive disease or controls. This increased number of plaque forming\u2010cells correlated with depressed serum C3 levels by Spearman rank\u2010order analysis. The finding of elevated numbers of spontaneous IgM plaque\u2010forming cells to defined chemical haptens supports the concept that active SLE demonstrates a generalized increase in B\u2010cell activity toward a variety of antigens.<\/jats:p>","DOI":"10.1002\/art.1780200312","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:03:44Z","timestamp":1171476224000},"page":"829-833","source":"Crossref","is-referenced-by-count":149,"title":["Increased spontaneous activity of antibody\u2010forming cells in the peripheral blood of patients with active sle"],"prefix":"10.1002","volume":"20","author":[{"given":"Daniel R.","family":"Budman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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