{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:12Z","timestamp":1762160592016},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":10432,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To characterize the pathology of muscle involvement in mixed connective tissue disease (MCTD), skeletal muscle biopsies from 13 patients with MCTD were examined by routine light microscopy, histochemistry, and direct immunofluorescence. The histologic and histochemical changes observed corresponded closely to changes seen in idiopathic polymyositis and the myopathy associated with systemic lupus erythematosus. Eight of 13 cases examined by direct immunofluorescence demonstrated immunoglobulin deposition either within normal appearing vessels, within normal fibers, around or on the sarcoplasmic membrane, or within the perimysial connective tissue. The histologic findings support Sharp's observation of the high incidence of focal inflammatory lesions in skeletal muscle biopsies of patients with MCTD. Immunoglobulin deposition in these muscle biopsies suggests an immunologic basis for the muscular symptomatology in MCTD.<\/jats:p>","DOI":"10.1002\/art.1780200411","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:03:25Z","timestamp":1171476205000},"page":"985-988","source":"Crossref","is-referenced-by-count":42,"title":["Pathology of skeletal muscle in mixed connective tissue disease"],"prefix":"10.1002","volume":"20","author":[{"given":"R.","family":"Oxenhandler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Corman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Adelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_3_2","first-page":"30","volume-title":"Muscle Biopsy. A Modern Approach","author":"Dubowitz V","year":"1973"},{"key":"e_1_2_1_4_2","first-page":"102","volume-title":"The pathologic interpretation of muscle histochemistry. The Striated Muscle","author":"Brooke MH","year":"1973"},{"key":"e_1_2_1_5_2","first-page":"236","volume-title":"Defined immunofluorescence in clinical immunopathology, Immunopathology of the Skin: Labeled Antibody Studies","author":"Beutner EH","year":"1973"},{"key":"e_1_2_1_6_2","first-page":"299","volume-title":"The pathologic substratum of polymyositis, The Striated Muscle","author":"Adams RD","year":"1973"},{"key":"e_1_2_1_7_2","first-page":"101","article-title":"Muscle pathology in rheumatoid arthritis, polymyalgia rheumatica, and polymyositis","volume":"94","author":"Brooke MH","year":"1972","journal-title":"Arch Pathol"},{"key":"e_1_2_1_8_2","unstructured":"OxenhandlerR AdelsteinE HartM: Immunopathology of skeletal muscle: the value of direct immunofluorescence in the diagnosis of connective tissue disease.Hum Pathol(in press)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-1-53"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197202172860701"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(75)80096-7"},{"key":"e_1_2_1_12_2","first-page":"919","volume-title":"Autoimmunity to heart, Textbook of Immunopathology","author":"Kaplan MH","year":"1976"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780200411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780200411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T12:41:51Z","timestamp":1700743311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780200411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,5]]}},"alternative-id":["10.1002\/art.1780200411"],"URL":"https:\/\/doi.org\/10.1002\/art.1780200411","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,5]]}}}