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Muscle enzymes were elevated, EMG was compatible with polymyositis, and muscle biopsy revealed an atypical necrotizing vacuolar myopathy. Synovial biopsy revealed an inflammatory synovitis with Class II synovial fluid. No mucin deposition was detectable in muscle or synovium. During 7 years of observation, corticosteroids and various immunosuppressive agents were successively administered with little benefit. Recently, weekly intravenous methotrexate and low\u2010dose oral corticosteroids have resulted in clinical and laboratory improvement. It is suggested that the pathology in papular mucinosis may include serious rheumatic manifestations in addition to the cutaneous involvement.<\/jats:p>","DOI":"10.1002\/art.1780200412","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:03:25Z","timestamp":1171476205000},"page":"989-996","source":"Crossref","is-referenced-by-count":30,"title":["Papular mucinosis with myopathy, arthritis, and eosinophilia"],"prefix":"10.1002","volume":"20","author":[{"given":"Lawrence P.","family":"Mcadam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl M.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Sadoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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