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The nuclei of many synoviocytes and histiocytes in rheumatoid synovial membrane were found to bind CRP. Cultures of rheumatoid synovium in <jats:sup>14<\/jats:sup>C\u2010labeled amino acids produced radioactive IgG, IgM, IgA, and C3, but not CRP, indicating the synovial\u2010bound CRP was not of local origin. A few CRP\u2010binding nuclei were present in one osteoarthritic synovium, but none was found in the other and none in synovium from the 4 non\u2010arthritic patients. The nature of the nuclear CRP ligand in rheumatoid synovium was not determined.<\/jats:p>","DOI":"10.1002\/art.1780200808","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:58:33Z","timestamp":1171475913000},"page":"1491-1499","source":"Crossref","is-referenced-by-count":64,"title":["Localization of C\u2010reactive protein in synovium of patients with rheumatoid arthritis"],"prefix":"10.1002","volume":"20","author":[{"given":"Jonathan D.","family":"Gitlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan I.","family":"Gitlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gitlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"120","article-title":"Radioimmunoassay of human C\u2010reactive protein and levels in normal sera","volume":"87","author":"Claus DR","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.54.2.558"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-114-28578"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.3.706"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.52.4.561"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.73.2.173"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35323"},{"key":"e_1_2_1_9_2","first-page":"2135","article-title":"Interaction of C\u2010reactive protein complexes with the complement system. 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