{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:59:38Z","timestamp":1759694378177},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":10118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence has been found to document the presence of circulating immune complexes in all patients with Felty's syndrome. The sera of all 12 patients studied showed intermediate complexes by analytical ultracentrifugation. The sera of 9 of 12 patients (75%) showed precipitin lines upon immunodiffusion against IgM rheumatoid factor. Both findings were statistically increased above those in a matched group of patients with classic rheumatoid arthritis. The presence of circulating immune complexes in the sera of the Felty patients was consistent with the observation that large inclusions containing IgG, IgM, and complement were phagocytized by normal polymorphonuclear cells when incubated with sera of Felty patients. Normal polymorphonuclear cells phagocytosed inclusions from 77% of Felty sera, compared with 27% of classic rheumatoid arthritis sera. It is suggested that the uptake of immune complexes by polymorphonuclear cells plays a role in the neutropenia of Felty's syndrome.<\/jats:p>","DOI":"10.1002\/art.1780210304","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:53:15Z","timestamp":1171475595000},"page":"310-315","source":"Crossref","is-referenced-by-count":28,"title":["Comparison Of The Presence Of Immune Complexes In Felty'S Syndrome And Rheumatoid Arthritis"],"prefix":"10.1002","volume":"21","author":[{"given":"Mario","family":"Andreis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Hurd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Lospalluto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Ziff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"16","article-title":"Chronic arthritis in adults associated with splenomegaly and leukopenia: a report of five cases of an unusual clinical syndrome","volume":"35","author":"Felty AR","year":"1924","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1961.10.4.292"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.4.359"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780050505"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110302"},{"key":"e_1_2_1_7_2","first-page":"275","article-title":"Clinical and hematologic study of Felty's syndrome","volume":"6","author":"Hahn RG","year":"1963","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"Perper RJ (ed): Mechanisms of tissue injury with reference to rheumatoid arthritis.Ann NY Acad Sci256:1\u2013450 1975","DOI":"10.1111\/j.2164-0947.1975.tb03053.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb05457.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130104"},{"key":"e_1_2_1_11_2","first-page":"187","article-title":"White cell antibodies and the etiology of Felty's syndrome","volume":"43","author":"Rosenthal FD","year":"1974","journal-title":"Q J Med"},{"key":"e_1_2_1_12_2","first-page":"1127","article-title":"Complement fixing granulocyte specific antinuclear factors in neutropenic cases of rheumatoid arthritis","volume":"26","author":"Wiik A","year":"1974","journal-title":"Immunology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06812.x"},{"key":"e_1_2_1_14_2","first-page":"413","article-title":"Phagocytosis of immune complexes by polymorphonuclear leukocytes in patients with Felty's syndrome","volume":"28","author":"Hurd ER","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_15_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130602"},{"key":"e_1_2_1_17_2","first-page":"1377","article-title":"Studies on monoclonal antibodies. II. immune complex IgM\u2010IgG cryoglobulinemia: the mechanisms of cryoprecipitation","volume":"113","author":"Stone MJ","year":"1974","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36036.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36037.x"},{"key":"e_1_2_1_20_2","first-page":"511","article-title":"Presence of aggregated \u03b3\u2010G globulin in certain rheumatoid synovial effusions","volume":"2","author":"Hannestad K","year":"1967","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170312"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780210304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780210304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:54:27Z","timestamp":1700751267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780210304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1002\/art.1780210304"],"URL":"https:\/\/doi.org\/10.1002\/art.1780210304","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4]]}}}