{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:19:02Z","timestamp":1790461142050,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":10118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nineteen patients with Sj\u00f6gren's syndrome were evaluated for the presence of HLA\u2010B8 and HLA\u2010Dw3. HLA\u2010B8 was found in 57.8% of patients and 20.1% of 96 controls (<jats:italic>P<\/jats:italic> &gt; 0.0001). HLA\u2010Dw3 was detected in 73.7% of the patients and 24.0% of controls (<jats:italic>P<\/jats:italic> &gt; 0.00001). Statistical evaluation of the association of both antigens with Sj\u00f6gren's syndrome revealed that the primary association was with HLA\u2010Dw3 (<jats:italic>P<\/jats:italic> &gt; 0.005). Patients with HLA\u2010Dw3 had a lower mean parotid salivary flow rate (0.8 \u00b1 0.3 ml\/10 minutes\/gland versus 5.6 \u00b1 1.2 ml\/10 minutes\/gland, <jats:italic>P<\/jats:italic> &lt; 0.00004) and a more intense lymphocytic infiltration into labial salivary glands (focus score 7.2 \u00b1 0.9 versus 3.4 \u00b1 0.9, <jats:italic>P<\/jats:italic> &lt; 0.04) than did patients without HLA\u2010Dw3. The difference in the intensity of the lymphocytic infiltration was even more significant when patients with both HLA\u2010Dw3 and HLA\u2010B8 were compared with patients with neither antigen (focus score 7.5 \u00b1 1.0 versus 2.8 \u00b1 0.8, <jats:italic>P<\/jats:italic> &lt; 0.02). In addition, all patients with severe keratoconjunctivitis sicca had both antigens. Our observations suggest that a number of genes may interact to determine susceptibility and severity in Sj\u00f6gren's syndrome.<\/jats:p>","DOI":"10.1002\/art.1780210308","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:53:15Z","timestamp":1171475595000},"page":"337-342","source":"Crossref","is-referenced-by-count":52,"title":["Relationship of Hla\u2010Dw3 and Hla\u2010B8 to Sj\u00f6gren'S Syndrome"],"prefix":"10.1002","volume":"21","author":[{"given":"Kenneth H.","family":"Fye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I.","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy E.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Opelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Talal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403072901008"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106958"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107123"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92149-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91450-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92548-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-39-6-1115"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.22.6.429"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190508"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1975.tb00653.x"},{"key":"e_1_2_1_13_2","unstructured":"Thorsby E Piazza A (editors): Joint Report from the Sixth International Histocompatibility Workshop Conference. II. Typing for HLA\u2010D (LD\u20101 or MLC) determinants. Histocompatibility Testing 1975. Edited by F Kissmeyer\u2010Nielsen. Copenhagen Ejnar Munksgaard 1975 pp414\u2013458"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.1.70"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/10731197409118956","article-title":"An advanced design of the Carleon\u2010Crittendon cup for collection of parotid saliva","volume":"2","author":"Sproles AC","year":"1974","journal-title":"Biomater Med Devices Artif Organs"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(75)90108-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196811000-00006"},{"key":"e_1_2_1_18_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197103000-00004"},{"key":"e_1_2_1_20_2","volume-title":"Comparison of MLC typing response indexes. Histocompatibility Testing","author":"Mickey MP","year":"1972"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01285.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01080.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.2.495"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197703032960902"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/262350b0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01073.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704212961602"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(74)90029-4"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780210308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780210308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:54:59Z","timestamp":1700751299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780210308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1002\/art.1780210308"],"URL":"https:\/\/doi.org\/10.1002\/art.1780210308","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4]]}}}