{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:34Z","timestamp":1760188834550},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":10118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Large amounts of fibrin are seen in the intima of the renal arterioles in progressive systemic sclerosis (scleroderma). The half\u2010life or half disappearance time of plasma fibrinogen in 15 patients with scleroderma was studied using <jats:sup>125<\/jats:sup>I fibrinogen to find whether there is an increased turnover of plasma fibrinogen paralleling this morphologic abnormality. Patients had a more rapid fibrinogen turnover than normal controls (60.7 versus 90.6 hours); the subgroup of patients with \u201cprogressive\u201d scleroderma had a more rapid fibrinogen half\u2010life than those with \u201cstable\u201d scleroderma (56.5 versus 73.2 hours). The mean fibrinogen half\u2010life of 8 patients given intravenous heparin increased to within one standard deviation of normal, a finding that suggested that the fibrinogen molecule in these patients was capable of normal survival. There was a considerable variation of fibrinogen half\u2010lives in individual scleroderma patients over time (not seen in the normal controls) which may be the result of intermittently increased fibrinogen consumption.<\/jats:p>","DOI":"10.1002\/art.1780210309","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:53:15Z","timestamp":1171475595000},"page":"343-347","source":"Crossref","is-referenced-by-count":14,"title":["Fibrinogen Turnover in Progressive Systemic Sclerosis"],"prefix":"10.1002","volume":"21","author":[{"given":"Geoffrey M.","family":"Gratwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Sergent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"209","article-title":"Progressive systemic sclerosis and malignant hypertension: an immunohistochemical study of renal lesions","volume":"72","author":"Fennel RH","year":"1961","journal-title":"Arch Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1975.36"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190211"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108566"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1963.12.103"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196909252811304"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104721"},{"key":"e_1_2_1_9_2","first-page":"531","article-title":"Effect of corticosteroids upon fibrinogen metabolism in rabbits","volume":"30","author":"Seligsohn V","year":"1973","journal-title":"Thrombos Diasthes Haemorrh"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1972.tb05715.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(75)90017-7"},{"key":"e_1_2_1_12_2","volume-title":"Pathology of the Kidney","author":"Heptinstall RH","year":"1974"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-2-317"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160506"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-6-895"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780210309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780210309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:55:01Z","timestamp":1700751301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780210309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1002\/art.1780210309"],"URL":"https:\/\/doi.org\/10.1002\/art.1780210309","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4]]}}}