{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:52:00Z","timestamp":1788310320644,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":10037,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism of granulocyte depletion in a patient with systemic lupus erythematosus and neutropenia was investigated. Neutrophil kinetic studies showed a shortened intravascular survival (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> of 1.6 hours) in the face of an increased marrow neutrophil pool. IgG bound to the patient's neutrophils, measured by the Fab anti\u2010F(ab)<jats:sub>2<\/jats:sub> assay, was nearly three times normal. The IgG neutrophil\u2010binding activity of the patient's serum was elevated in serial samples obtained over two years. In addition, his serum was able to opsonize normal neutrophils for ingestion by other neutrophils as detected by <jats:sup>14<\/jats:sup>C\u20101\u2010glucose oxidation. Enhanced IgG PMN\u2010binding activity was observed with sucrose density gradient fractions of the patient's serum containing either large complexes (19S or greater in size), intermediate complexes (between 7S and 19S), or monomeric IgG. Only the monomeric IgG fraction from the patient's serum, however, opsonized normal neutrophils for ingestion by other neutrophils. These results support the hypothesis that anti\u2010cell antibodies were responsible for the neutropenia in this patient by opsonizing neutrophils for ingestion by other phagocytic cells.<\/jats:p>","DOI":"10.1002\/art.1780210503","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:19:09Z","timestamp":1171477149000},"page":"504-512","source":"Crossref","is-referenced-by-count":43,"title":["Autoimmune neutropenia in systemic lupus erythematosus"],"prefix":"10.1002","volume":"21","author":[{"given":"Gordon","family":"Starkebaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Arend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-2-220"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1182\/blood.V18.6.672.672","article-title":"Study of leukopenias and thrombocytopenias by the direct antiglobulin consumption test on leukocytes and or platelets","volume":"18","author":"Dausset J","year":"1961","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180609"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V6.11.1059.1059"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-4-437"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-1-60"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510092931505"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108517"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107993"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197001000-00002"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104167"},{"issue":"97","key":"e_1_2_1_15_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"B\u00f6yum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_16_2","first-page":"254","article-title":"Enhancement of in vitro immunoglobulin synthesis of human lymphocytes by lysosomal enzymes from polymorphonuclear leukocytes","volume":"27","author":"Yamasahi K","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4049\/jimmunol.104.2.367","article-title":"The measurement of immunoglobulin associated with human peripheral lymphocytes","volume":"104","author":"Smith RS","year":"1970","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.109.6.1386","article-title":"Immunoglobulin synthesis by human lymphoid tissues: normal bone marrow as a major site of IgG production","volume":"109","author":"McMillan R","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(70)90248-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.6.1465"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107704"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00772a008"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197411282912203"},{"key":"e_1_2_1_24_2","volume-title":"Examination of the peripheral blood. 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