{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:33:00Z","timestamp":1791289980627,"version":"4.3.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9945,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lactic acid concentrations in the synovial fluid of 84 patients with acute monoarticular arthritis were determined by gas liquid chromatography. Lactic acid values in 27 cases of nongonococcal septic arthritis were strikingly higher (mean 1170 mg\/100 ml) than in 45 cases of inflammatory or degenerative arthritis (mean 34 mg\/100 ml), as well as in 12 cases of gonococcal arthritis (mean 27 mg\/100 ml). With the proper equipment, determination of lactic acid can be a relatively rapid, reliable procedure. Synovial fluid lactic acid concentrations therefore can be used as a rapid, supplemental diagnostic aid in differentiating nongonococcal septic arthritis from both gonococcal and nonseptic acute arthritis.<\/jats:p>","DOI":"10.1002\/art.1780210706","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:17:08Z","timestamp":1171477028000},"page":"774-779","source":"Crossref","is-referenced-by-count":66,"title":["Synovial fluid lactic acid. a diagnostic aid in septic arthritis"],"prefix":"10.1002","volume":"21","author":[{"given":"Itzhak","family":"Brook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Bricknell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Bluestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney M.","family":"Finegold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140407"},{"key":"e_1_2_1_3_2","first-page":"503","article-title":"Pathways of glucose metabolism in rheumatic and non\u2010rheumatic synovial membrane","volume":"70","author":"Roberts JE","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170416"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106912"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1974.02110270025006"},{"key":"e_1_2_1_7_2","first-page":"194","article-title":"Rapid diagnosis of meningitis by gas liquid chromatographic analysis of cerebrospinal fluid lactic acid","volume":"31","author":"Controni G","year":"1975","journal-title":"C1 Proc Child Hosp Nat Med Ctr"},{"key":"e_1_2_1_8_2","first-page":"396","article-title":"Spinal fluid lactic acid, a diagnostic acid in bacterial meningitis","volume":"10","author":"Brook I","year":"1975","journal-title":"Pediatr Res"},{"key":"e_1_2_1_9_2","first-page":"175","article-title":"1958 Revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_10_2","unstructured":"BricknellKS SugiharaPT BrookI: Optimizing methylation conditions for gas\u2010liquid chromatography assay of lactic acid in biological samples.Abstr of Annual Meeting Amer Soc Microbiology 1976p44"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130606"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80078-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140107"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780210706","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780210706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T13:13:09Z","timestamp":1700745189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780210706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1002\/art.1780210706"],"URL":"https:\/\/doi.org\/10.1002\/art.1780210706","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]}}}