{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:43:16Z","timestamp":1770694996185,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9884,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifteen to twenty percent of patients with juvenile rheumatoid arthritis (JRA) have positive latex fixation tests (LFT), whereas approximately 46% have previously been demonstrated to have hidden rheumatoid factors (RF), i.e., 19S IgM RF which can be detected by the LFT after acid separation of the IgM\u2010containing fraction from serum. In this study, hidden RF were found in 59% of patients with seronegative JRA by use of a complement\u2010dependent hemolytic assay. The median titer of JRA patients was 1:42, and in healthy and disease controls it was 1:7. The difference was significant at P &lt; 0.001. When data from patients with active disease were analyzed separately, the median titer for polyarticular JRA was 1:97 and for pauciarticular JRA, 1:91. The differences due to active disease were significant at P &lt; 0.001 and P &lt; 0.005, respectively.<\/jats:p><jats:p>The results demonstrate that the hemolytic assay is more sensitive than the LFT in determining the presence of hidden RF, and activity of disease correlates well with high hemolytic RF titers.<\/jats:p>","DOI":"10.1002\/art.1780210810","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:15:44Z","timestamp":1171476944000},"page":"935-941","source":"Crossref","is-referenced-by-count":24,"title":["Complement\u2010fixing hidden rheumatoid factor in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"21","author":[{"given":"Terry L.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Zuckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Baldassare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry D.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"189","article-title":"Report of studies on juvenile rheumatoid arthritis","volume":"20","author":"Levinson JR","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090603"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92331-9"},{"key":"e_1_2_1_5_2","first-page":"651","article-title":"Hidden anti\u2010globulins in rheumatic disorders","volume":"7","author":"Cracchiolo A","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.3.255"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107949"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210713"},{"key":"e_1_2_1_9_2","first-page":"195","article-title":"Current proposed revision of JRA criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Section of the Arthritis Foundation","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210118"},{"key":"e_1_2_1_11_2","first-page":"888","article-title":"The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis","volume":"21","author":"Singer JM","year":"1956","journal-title":"Am J Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(50)91500-5"},{"key":"e_1_2_1_13_2","first-page":"217","volume-title":"Introduction to Biostatistics","author":"Sokal RR","year":"1973"},{"key":"e_1_2_1_14_2","first-page":"204","article-title":"A study of complement fixation by rheumatoid factor using a hemolytic assay system","volume":"28","author":"Taylor\u2010Upsahl MM","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_15_2","first-page":"309","article-title":"The binding constants of IgM rheumatoid factors and their univalent fragments for native and aggregated human IgG","volume":"32","author":"Dissanayake S","year":"1977","journal-title":"Immunology"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200807"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200214"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780210810","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780210810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:13:59Z","timestamp":1700748839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780210810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1978,11]]}},"alternative-id":["10.1002\/art.1780210810"],"URL":"https:\/\/doi.org\/10.1002\/art.1780210810","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,11]]}}}