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A twofold decrease in both proportion and absolute number of T\u03b3 cells was found in patients with active systemic lupus erythematosus (SLE) relative to values obtained during disease remission. The reduction in T\u03b3 cells was most evident in patients with severe hypocomplementemia. A deficit of T\u03b3 cells in active patients was not demonstrated. The percentage of total T cells rosetting with sheep erythrocytes was reduced in peripheral blood of most patients regardless of disease activity status, but particularly during SLE exacerbation. Cells lacking intrinsic surface immunoglobulin, IgG Fc receptors, and receptors for sheep erythrocytes were increased. These cells, operationally termed null. exhibited an inverse linear relationship with T cells that was not apparent in regression analyses performed against other lymphocyte subpopulations. Such differences were not found for B cells and IgG receptor\u2010bearing non\u2010B\/non\u2010T cells which were present in normal proportions in virtually all patients. The origin and functional significance of these unusual lymphocyte subpopulation abnormalities are discussed.<\/jats:p>","DOI":"10.1002\/art.1780220101","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:13:00Z","timestamp":1171476780000},"page":"1-6","source":"Crossref","is-referenced-by-count":47,"title":["T\u03b3 cells in systemic lupus erythematosus"],"prefix":"10.1002","volume":"22","author":[{"given":"Maurice E.","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Winfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.184"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.4049\/jimmunol.119.5.1778","article-title":"Fc receptor heterogeneity: immunofluorescent studies of B, T, and \u201cthird population\u201d lymphocytes in human blood with rabbit IgG b4\/anti\u2010b4 complexes.","volume":"119","author":"Winfield JB","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus.","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_5_2","first-page":"462","article-title":"Assessment of disease activity in systemic lupus erythematosus (SLE)","volume":"15","author":"Winfield JB","year":"1972","journal-title":"Arthritis Rheum"},{"issue":"97","key":"e_1_2_1_6_2","first-page":"77","article-title":"Separation of leukocytes from blood and bone marrow.","volume":"21","author":"Bo\u00ffum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107852"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(72)90006-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4049\/jimmunol.114.4.1210","article-title":"IgG on lymphocyte surfaces: technical problems and the significance of a third cell population.","volume":"114","author":"Winchester RJ","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(73)90007-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000231207"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4049\/jimmunol.117.4.1331","article-title":"Reversal of cell surface abnormalities of T lymphocytes in Hodgkin's disease after in vitro incubation in fetal sera.","volume":"117","author":"Fuks Z","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107184"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90083-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180402"},{"key":"e_1_2_1_17_2","first-page":"317","article-title":"Antibody\u2010dependent direct cytotoxicity of human lymphocytes. 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Studies on peripheral blood lymphocytes and sera of patients with systemic lupus erythematosus.","volume":"24","author":"Scheinberg MA","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_18_2","first-page":"228","article-title":"Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient.","volume":"26","author":"Glinski W","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200602"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190606"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210935"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.5.1092"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108391"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180609"},{"key":"e_1_2_1_25_2","first-page":"175","article-title":"Relationship of lymphopenia and parameters of disease activity in systemic lupus erythematosus.","volume":"3","author":"Utsinger PD","year":"1976","journal-title":"J Rheumatol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91491-9"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(76)90088-X"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.5.422"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180305"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200312"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210109"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830050812"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(76)90110-0"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108607"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.302032"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108316"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.4049\/jimmunol.119.6.1943","article-title":"Changes of Fc\u03b3 receptor\u2010related properties induced by interaction of human lymphocytes with insoluble immune complexes.","volume":"19","author":"Cordier G","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/272618a0"},{"key":"e_1_2_1_39_2","first-page":"520A","article-title":"Transition of T\u03b3 to T\u03bc cells.","volume":"26","author":"Pichler WJ","year":"1978","journal-title":"Clin Res"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780220101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780220101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:49:07Z","timestamp":1700725747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780220101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/art.1780220101"],"URL":"https:\/\/doi.org\/10.1002\/art.1780220101","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}