{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:36Z","timestamp":1761155016264},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9823,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>All but one of 28 patients with mixed connective tissue disease (MCTD) who were studied prospectively had arthralgia, and 15 of them had noticed joint swelling. Arthralgia was the first symptom in 14 patients and one of the first two symptoms in 24. Arthralgia was pauciarticular in 4 and polyarticular in 23. Presence of morning stiffness in 15 patients, symmetrical joint swelling in 16, joint deformity in 6, marginal erosions in roentgenograms of the hands of 12, rheumatoid factor in 25, and subcutaneous nodules in 5 caused 24 of the 28 patients with MCTD to fulfill criteria for definite or classic rheumatoid arthritis. All patients, however, also had prominent signs or symptoms of scleroderma, systemic lupus erythematosus, or polymyositis.<\/jats:p>","DOI":"10.1002\/art.1780220107","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:13:00Z","timestamp":1171476780000},"page":"43-51","source":"Crossref","is-referenced-by-count":53,"title":["Articular manifestations of mixed connective tissue disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Francisco","family":"Ramos\u2010Niembro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Alarc\u00f3an\u2010Segovia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Hern\u00e1ndez\u2010Ort\u00edz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_3_2","first-page":"191","article-title":"Symptomatic Sj\u00f6gren's syndrome in mixed connective tissue disease.","volume":"3","author":"Alarc\u00f3n\u2010Segovia D","year":"1976","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","first-page":"828","article-title":"Mixed connective tissue disease.","volume":"25","author":"Sharp GC","year":"1975","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1978.02120280047010"},{"key":"e_1_2_1_6_2","first-page":"404","article-title":"The evolving clinical spectrum of mixed connective tissue disease (abstract).","volume":"18","author":"Hench PK","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_7_2","first-page":"355","article-title":"Mixed connective tissue disease in children.","volume":"20","author":"Singsen BH","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210502"},{"key":"e_1_2_1_9_2","first-page":"4","article-title":"Cold\u2010reactive lymphocytotoxic antibodies in mixed connective tissue disease.","volume":"4","author":"D\u00edaz\u2010Jouanen E","year":"1977","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb19002.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(72)90013-X"},{"key":"e_1_2_1_12_2","first-page":"888","article-title":"Latex fixation test: application to the serologic diagnosis of rheumatoid arthritis.","volume":"21","author":"Singer JM","year":"1956","journal-title":"Am J Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_1_14_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis.","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_15_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus.","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_16_2","unstructured":".Ramos\u2010NiembroF Alarc\u00f3n\u2010SegoviaD: Familial aspects of mixed connective tissue disease (MCTD). I. Occurrence of systemic lupus erythematosus in another member in two families and aggregation of MCTD in another family.J Rheumatol in press"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197103000-00001"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_1_20_2","first-page":"97","article-title":"Synovial tissue changes and rheumatoid factor in scleroderma.","volume":"46","author":"Clark JA","year":"1971","journal-title":"Mayo Clin Proceed"},{"key":"e_1_2_1_21_2","unstructured":".Alarc\u00f3n\u2010SegoviaD FishbeinE Fr\u00edesV: Unpublished observations"},{"key":"e_1_2_1_22_2","unstructured":".Alarc\u00f3n\u2010SegoviaD FishbeinE Fr\u00edesV Ramos\u2010NiembroF: Antibodies to extractable nuclear antigens (ENA) in systemic lupus erythematosus Abstract 65. 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