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After careful removal of all subcutaneous fatty tissue, the skin cores were weighed and their water and hydroxyproline content determined. Despite recent claims to the contrary, it was found that there is a marked and highly significant increase in the thickness of the skin during the indurative phase of PSS, and that this is associated with a proportionate increase in total dermal collagen content. A similar degree of thickening was found in the skin of patients with eosinophilic fasciitis and acromegaly. A close correlation was observed between clinical estimation of the degree of skin thickening and the weight of the skin biopsy cores. Change in the weight of skin cores was observed during the course of illness of the patients with PSS and may serve as a useful measurement of alteration in the degree of skin thickening.<\/jats:p>","DOI":"10.1002\/art.1780220205","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:48:52Z","timestamp":1171478932000},"page":"130-140","source":"Crossref","is-referenced-by-count":270,"title":["Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma"],"prefix":"10.1002","volume":"22","author":[{"given":"Gerald P.","family":"Rodnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lipinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Luksick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"310","volume-title":"Pathology, Diagnosis, and Treatment.","author":"Crocker HR","year":"1888"},{"key":"e_1_2_1_3_2","first-page":"1100","volume-title":"The Histopathology of the Diseases of the Skin.","author":"Unna PG","year":"1896"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1957.01550130080008"},{"key":"e_1_2_1_5_2","first-page":"962","volume-title":"Arthritis and Allied Conditions.","author":"Rodnan GP","year":"1972"},{"key":"e_1_2_1_6_2","first-page":"263","article-title":"Note sur la scl\u00e9rodermie.","volume":"2","author":"Gintrac E","year":"1847","journal-title":"Rev Med\u2010Chir (Paris)"},{"key":"e_1_2_1_7_2","first-page":"294","article-title":"Zur pathologischen Anatomie des Scleroma der Haut bei Erwachsenen.","volume":"2","author":"Foerster A","year":"1861","journal-title":"W\u00fcrzb Med Z"},{"key":"e_1_2_1_8_2","first-page":"739","article-title":"Ein Beitrag zur Lehre vom Haut\u2010Sklerem der Erwachsenen.","volume":"13","author":"Auspitz H","year":"1863","journal-title":"Wien Med Wochenshr"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780030607"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108594"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01590270123028"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb15741.x"},{"key":"e_1_2_1_13_2","first-page":"69","article-title":"Skin thickness and collagen content in some endocrine, connective tissue and skin diseases. 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