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When C3 was corrected for total protein, the levels for rheumatoid arthritis, Reiter's disease, psoriatic arthritis, and systemic lupus were significantly different from degenerative arthritis. When C3 was corrected for synovial fluid globulin, only rheumatoid arthritis and systemic lupus were significantly different from degenerative arthritis. Correction of C3 for globulin increases the difference between rheumatoid arthritis and degenerative arthritis. A proportion of gouty fluids with a relative decrease in C3 is demonstrated. It is argued that correction of C3 for globulin is more meaningful than correction for total protein. While many nonrheumatoid inflammatory effusions demonstrate split products of C3, the majority of fluids from patients with systemic lupus have none.<\/jats:p>","DOI":"10.1002\/art.1780220306","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:48:09Z","timestamp":1171478889000},"page":"243-250","source":"Crossref","is-referenced-by-count":19,"title":["Immunoelectrophoretic assay for synovial fluid C3 with correction for synovial fluid globulin"],"prefix":"10.1002","volume":"22","author":[{"given":"Peter","family":"Hasselbacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009746309165107"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105013"},{"key":"e_1_2_1_4_2","first-page":"715","article-title":"Synovial fluid complement determination as a diagnostic aid in inflammatory joint disease.","volume":"49","author":"Bunch TW","year":"1974","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-1-32"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080206"},{"key":"e_1_2_1_7_2","first-page":"160","article-title":"Activation of complement components C3 and factor B in synovial fluids.","volume":"89","author":"Hunder GG","year":"1977","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200202"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130601"},{"key":"e_1_2_1_10_2","first-page":"413","article-title":"Levels of complement components, properdin factors, and kininogen in patients with inflammatory arthritis.","volume":"1","author":"Rynes RI","year":"1974","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180401"},{"key":"e_1_2_1_12_2","first-page":"23","article-title":"Complement in synovial fluid.","volume":"127","author":"Townes AS","year":"1970","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_13_2","first-page":"407","article-title":"Studies of the third component of complement in synovial fluid from arthritic patients. 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