{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:22:21Z","timestamp":1791238941257,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":9721,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera from 20 patients with systemic lupus erythematosus (SLE) and active central nervous system (CNS) dysfunction were examined by indirect immunofluorescence for antibodies to neuronal membrane determinants. Warm\u2010reactive IgG antibodies were demonstrable in 82% (9\/11) of patients with clinical evidence for seizures or diffuse CNS disease, but these antibodies generally were absent in non\u2010CNS SLE sera or when focal neurologic deficit or psychosis was the primary CNS manifestation. Cold\u2010reactive antibodies of the IgM class were equally prevalent in patients with or without CNS disease and appeared to be more directly correlated with extra\u2010CNS systemic illness. Absorption experiments with lymphocytes, brain homogenate, and various other tissues suggested a predominant brainspecificity for IgG antibodies and partial lymphocyte cross\u2010reactivity for IgM antibodies. Interpretations of this special association between IgG anti\u2010brain antibodies and diffuse CNS dysfunction in SLE are discussed.<\/jats:p>","DOI":"10.1002\/art.1780220504","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:46:49Z","timestamp":1171478809000},"page":"458-462","source":"Crossref","is-referenced-by-count":116,"title":["Association of IgG Anti\u2010Brain Antibodies with Central Nervous System Dysfunction in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"22","author":[{"given":"H. Alexander","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Winfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Lahita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Koffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-1-65"},{"key":"e_1_2_1_3_2","first-page":"547","article-title":"Immunoperoxidase staining of the choroid plexus in systemic lupus erythematosus (abstract).","volume":"21","author":"Boyer RS","year":"1978","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210301"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160411"},{"key":"e_1_2_1_6_2","first-page":"369","article-title":"Central nervous system involvement in SLE.","volume":"20","author":"Small P","year":"1978","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196807000-00002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230889"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108303"},{"key":"e_1_2_1_10_2","first-page":"333","article-title":"Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.","volume":"30","author":"Bresnihan B","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_11_2","first-page":"109","article-title":"Antineuronal activity in SLE (abstract).","volume":"20","author":"Bluestein HG","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_12_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus.","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-7751-5_5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(72)90006-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4049\/jimmunol.114.4.1210","article-title":"IgG on lymphocyte surfaces: technical problems and the significance of a third cell population.","volume":"114","author":"Winchester RJ","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180101"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197701000-00003"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.4049\/jimmunol.118.6.1995","article-title":"Interspecies neural membrane antigens on cultured human and murine neuroblastoma cells.","volume":"118","author":"Akeson R","year":"1977","journal-title":"J Immnunol"},{"key":"e_1_2_1_19_2","first-page":"1750","article-title":"Reactivity of human brain antiserum with neuroblastoma cells and non\u2010reactivity with thymocytes and lymphocytes.","volume":"37","author":"Casper JT","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-5-616"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.982041"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.191911"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90885-4"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780220504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780220504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:03:23Z","timestamp":1700723003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780220504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,5]]}},"alternative-id":["10.1002\/art.1780220504"],"URL":"https:\/\/doi.org\/10.1002\/art.1780220504","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,5]]}}}