{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:51:47Z","timestamp":1759481507694},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":9721,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circulating immune complexes were measured by three assays (monoclonal rheumatoid factor radioimmunoassay, Clq\u2010binding assay, Raji cell radioassay) in sera from patients with mixed connective tissue disease. Evidence for circulating immune complexes was found by at least one method in 94% of sera. The highest frequency of positive results was noted by the Raji cell radioassay (88%). However, a significant number of patients also had immune complexes measured by the Clq\u2010binding assay (50%) and monoclonal rheumatoid factor radioimmunoassay (45%). Further, the levels of immune complexes as measured by the Raji cell radioassay, and to a lesser extent the Clq\u2010binding assay, correlated with disease activity and represent a potentially useful clinical tool. The pattern of reactivity in mixed connective tissue disease sera differed from rheumatoid arthritis, scleroderma, and polymyositis. This suggests that a spectrum of immune complexes is found in these rheumatic diseases and supports the concept that mixed connective tissue disease is distinct from these diseases.<\/jats:p>","DOI":"10.1002\/art.1780220507","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:46:49Z","timestamp":1171478809000},"page":"484-489","source":"Crossref","is-referenced-by-count":28,"title":["Circulating Immune Complexes in Mixed Connective Tissue Disease"],"prefix":"10.1002","volume":"22","author":[{"given":"James T.","family":"Halla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Volanakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph E.","family":"Schrohenloher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0307-742X(21)00143-0","article-title":"Mixed connective tissue disease.","volume":"1","author":"Sharp GC","year":"1975","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_4_2","unstructured":".KasepGI SurgeonN AgnelloV: Serologic tests that correlate with clinical activity in mixed connective tissue disease (abstract 69). Proceedings of the XIV International Congress of Rheumatology San Francisco 1977"},{"key":"e_1_2_1_5_2","first-page":"130","article-title":"Circulating complement\u2010fixing immune complexes in mixed connective tissue disease (abstract).","volume":"20","author":"Parker MD","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_6_2","first-page":"374A","article-title":"Immune complexes in patients with progressive systemic sclerosis and mixed connective tissue disease.","volume":"26","author":"Cunningham PH","year":"1978","journal-title":"Clin Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108399"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.5.1230"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.5.1490"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197611182952101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.5.800"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4049\/jimmunol.106.2.304","article-title":"Clq: rapid purification method for preparation of monospecific antiserum and for biochemical studies.","volume":"106","author":"Yonemasu K","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","first-page":"660","volume-title":"Manual of Clinical Immunology.","author":"Tan EM","year":"1976"},{"key":"e_1_2_1_14_2","first-page":"888","article-title":"The latex fixation test. 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Application to the serological diagnosis of rheumatoid arthritis.","volume":"21","author":"Singer JM","year":"1956","journal-title":"Am J Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3843.806"},{"key":"e_1_2_1_16_2","first-page":"226","article-title":"Immune complex detection and complement activity in rheumatoid arthritis: a comparative study of a radioimmunoassay using monoclonal rheumatoid factor, gel diffusion techniques and C4 activity.","volume":"34","author":"Halla JT","year":"1978","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1130299"},{"key":"e_1_2_1_18_2","volume-title":"Protides of Biological Fluids, 26th Colloquium.","author":"Stagno S","year":"1978"},{"key":"e_1_2_1_19_2","volume-title":"Protides of the Biological Fluids, 26th Colloquium.","author":"Volanakis JE","year":"1978"},{"key":"e_1_2_1_20_2","first-page":"55A","article-title":"Immune complex detection in rheumatoid arthritis: a comparison of five methods.","volume":"26","author":"Halla JT","year":"1978","journal-title":"Clin Res"},{"key":"e_1_2_1_21_2","first-page":"157","volume-title":"Modern Topics in Rheumatology.","author":"Reichlin M","year":"1976"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197701000-00002"},{"key":"e_1_2_1_23_2","first-page":"357A","article-title":"An immunospecific clearance defect in patients with systemic lupus erythematosus related to the levels of circulating immune complexes.","volume":"25","author":"Frank MM","year":"1977","journal-title":"Clin Res"},{"key":"e_1_2_1_24_2","first-page":"404","article-title":"The evolving clinical spectrum of mixed connective tissue (abstract).","volume":"18","author":"Hirsch PK","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1084\/jem.134.3.286","article-title":"Occurrence of \u03b3\u2010globulin complexes in serum and synovial fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration.","volume":"134","author":"Winchester RJ","year":"1971","journal-title":"J Exp Med"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90542-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108112"},{"key":"e_1_2_1_28_2","first-page":"909","article-title":"Precipitation reactions of the Clq component of complement with aggregated\u2010\u03b3\u2010globulin and immune complexes in gel diffusion.","volume":"19","author":"Agnello V","year":"1970","journal-title":"Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780220507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780220507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:03:43Z","timestamp":1700723023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780220507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,5]]}},"alternative-id":["10.1002\/art.1780220507"],"URL":"https:\/\/doi.org\/10.1002\/art.1780220507","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,5]]}}}