{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:43:41Z","timestamp":1700725421137},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":9660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera from patients with Felty's syndrome (FS) and rheumatoid arthritis (RA) were examined for the presence of circulating immune complexes (IC) by using the <jats:sup>125<\/jats:sup>I\u2010C1<jats:sub>q<\/jats:sub> binding and monoclonal rheumatoid factor (mRF) techniques. Of 15 patients with FS, 9 (60%) had high <jats:sup>125<\/jats:sup>I\u2010C1<jats:sub>q<\/jats:sub> binding as compared to 3 of 26 RA patients (12%). The average C1<jats:sub>q<\/jats:sub> binding was significantly higher in the FS patients than in the RA patients without FS. C1<jats:sub>q<\/jats:sub> binding in both FS and RA patients was significantly higher than a group of 90 normal controls. In addition, serum C4 levels were significantly lower in the FS patients than in the RA patients. In contrast to these findings, IC levels in FS and RA patients were very similar when measured by the mRF technique. These studies indicate that FS patients have higher levels of complement\u2010fixing IC in their sera than RA patients without FS. These findings raise the possibility that the complement\u2010fixing IC found in these patients may play a role in the pathogenesis of the neutropenia of FS.<\/jats:p>","DOI":"10.1002\/art.1780220702","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:41:27Z","timestamp":1171478487000},"page":"697-702","source":"Crossref","is-referenced-by-count":22,"title":["Increased C1<sub>q<\/sub> binding immune complexes in felty's syndrome"],"prefix":"10.1002","volume":"22","author":[{"given":"Eric R.","family":"Hurd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chubick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo E.","family":"Jasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Ziff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb05457.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06812.x"},{"key":"e_1_2_1_4_2","first-page":"105","article-title":"The role of immune complexes in production of the neutropenia of Felty's syndrome (abstract)","volume":"1","author":"Hurd ER","year":"1974","journal-title":"J Rheumatol (Suppl 1)"},{"key":"e_1_2_1_5_2","first-page":"413","article-title":"Phagocytosis of immune complexes by polymorphonuclear leukocytes in patients with Felty's syndrome","volume":"28","author":"Hurd ER","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210304"},{"key":"e_1_2_1_7_2","first-page":"26","article-title":"Presence of leukocyte inclusions in spleen and bone marrow of patients with Felty's syndrome","volume":"5","author":"Hurd ER","year":"1978","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","first-page":"383","article-title":"Comparison of the presence of immune complexes in Felty's syndrome and rheumatoid arthritis (abstract)","volume":"18","author":"Andreis M","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4049\/jimmunol.116.1.232","article-title":"Detection of immune complexes in unheated sera by a modified 125I\u2010C1q binding test: effect of heating on the binding of C1q by immune complexes and application of the test to systemic lupus erythematosus","volume":"116","author":"Zubler RA","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4049\/jimmunol.106.2.304","article-title":"Rapid purification method for preparation of nonspecific antisera for biochemical studies","volume":"106","author":"Yonemasu K","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.4049\/jimmunol.110.3.820","article-title":"Effect of chemical and enzymatic radioiodination on in vitro human C1q activities","volume":"110","author":"Heusser C","year":"1973","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104061"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108112"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104721"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-72-17420"},{"key":"e_1_2_1_17_2","first-page":"550","article-title":"An immunofluorescence assay for double\u2010stranded DNA antibodies using the Crithidia luciliae kinetoplast as a double\u2010stranded DNA substrate","volume":"91","author":"Sontheimer R","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_2","unstructured":"BucknallRC BaconPA DavisP CummingRHCirculating immune complexes in Felty's syndrome (abstract #3) XIV International Congress on Rheumatology. 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