{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:51Z","timestamp":1760188851364},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":9660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood lymphocyte functions were evaluated in 20 patients with active polymyalgia rheumatica (PMR) and\/or giant cell arteritis (GCA) by determining the percent of E\u2010rosette\u2010forming cells and by measuring the uptake of tritiated thymidine by peripheral blood lymphocytes after exposure to common infectious antigens and to homogenates of homologous and heterologous artery, muscle, and elastin. Although lymphocytes from patients with PMR and\/or GCA were stimulated slightly by artery and muscle homogenates, no differences in lymphocyte responses were found when the results were compared with 22 normal controls and 16 patients with rheumatoid arthritis. The hypothesis that GCA results from a cellular immune reaction to normal or diseased arterial wall antigens is not supported by these studies.<\/jats:p>","DOI":"10.1002\/art.1780220708","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:41:27Z","timestamp":1171478487000},"page":"740-745","source":"Crossref","is-referenced-by-count":25,"title":["Cellular immunity in polymyalgia rheumatica and giant cell arteritis"],"prefix":"10.1002","volume":"22","author":[{"given":"Christos C.","family":"Papaioannou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene G.","family":"Hunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic C.","family":"Mcduffie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.26.2.103"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"On arteritis with special reference to polymyalgia rheumatica","volume":"237","author":"\u00d6stberg G","year":"1973","journal-title":"Acta Pathol Microbiol Scand Suppl"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/15.4.270"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31331-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-2-162"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197101000-00001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(58)92165-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-6-806"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-77-6-845"},{"key":"e_1_2_1_11_2","first-page":"157","article-title":"Degeneration of elastic fibers in granulomatous giant cell arteritis (temporal arteritis)","volume":"54","author":"Kimmelstiel P","year":"1952","journal-title":"Arch Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490170010003"},{"key":"e_1_2_1_13_2","first-page":"57","article-title":"Light and electron microscopic studies on human temporal arteries with special reference to alterations related to senescence, atherosclerosis, and giant cell arteritis","volume":"79","author":"Parker F","year":"1975","journal-title":"Am J Pathol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/207311a0"},{"key":"e_1_2_1_15_2","first-page":"434","article-title":"Sequential degradation and phagocytosis of heterologous elastin","volume":"89","author":"Papajiannis SP","year":"1970","journal-title":"Arch Pathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.2.122"},{"key":"e_1_2_1_17_2","first-page":"175","article-title":"Revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_18_2","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"97","author":"B\u00f6yum A","year":"1968","journal-title":"Scand J Clin Lab Invest 21 Suppl"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.207"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108283"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108607"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303012880903"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107057"},{"key":"e_1_2_1_24_2","first-page":"286","article-title":"Polymyalgia rheumatica and giant cell arterits: lack of response of peripheral blood lymphocytes to arterial wall homogenate (abstract)","volume":"36","author":"Zilko P","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-1-19"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1976.tb00110.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.2.158"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1001\/jama.1976.03270170042025","article-title":"Serum levels of immunoglobulin and complement in giant cell arteritis","volume":"236","author":"Malmvall BE","year":"1976","journal-title":"JAMA"}],"container-title":["Arthritis &amp; 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