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These determinations were always low and correlated with elevated IgG concentrations, suggesting nonspecific adherence of IgG rather than a true antigen\u2010antibody reaction. In support of this conclusion, nonrheumatoid factor IgG was capable of concentration\u2010dependent nonspecific adsorption to the solid phase. IgG, but not IgM, rheumatoid factor corresponded with disease activity in patients with seropositive rheumatoid arthritis, suggesting that IgG rheumatoid factor may be important in the pathogenesis.<\/jats:p>","DOI":"10.1002\/art.1780220907","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:41:04Z","timestamp":1171478464000},"page":"988-998","source":"Crossref","is-referenced-by-count":71,"title":["IgG rheumatoid factor"],"prefix":"10.1002","volume":"22","author":[{"given":"Richard M.","family":"Pope","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra J.","family":"Mcduffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104780"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105364"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.2.517"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4049\/jimmunol.115.2.365","article-title":"The molecular basis of self\u2010association of IgG rheumatoid factors","volume":"115","author":"Pope RM","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_6_2","first-page":"249","article-title":"Characterization of IgG complexes in eluates from rheumatoid tissue","volume":"8","author":"Munthe E","year":"1971","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1972.tb01813.x"},{"key":"e_1_2_1_8_2","first-page":"671","article-title":"Rheumatoid factor reacting with autologous native \u03b3G\u2010globulin and joint fluid \u03b3G aggregates","volume":"3","author":"Hannestad K","year":"1968","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","first-page":"689","article-title":"Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels","volume":"6","author":"Winchester RJ","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36036.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210921"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.26.4.334"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.28.4.424"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90524-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.31.2.129"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5977.203"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210119"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747609099903"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000231833"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.3.240"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90059-X"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.3.258"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4049\/jimmunol.120.3.739","article-title":"Nonspecific protein\u2010protein interaction of IgG: studies of the binding of IgG to IgG immunoadsorbants","volume":"120","author":"Nardella FA","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_24_2","first-page":"417","volume-title":"Is the insolubilized IgG technique valid for the detection of antiglobulins? 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