{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:54Z","timestamp":1760188854256},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9550,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four patients with active, severe rheumatoid arthritis were subjected to the removal of circulating lymphocytes (lymphapheresis) for a 6\u2010week period by use of a continuous flow cell centrifuge. Repetitive venous access was gained through forearm arteriovenous fistulae. In all patients the Ritchie\u2010Camp articular index declined rapidly in the first week and more slowly thereafter for a total mean drop of 61% below the initial value. The index continued to decline after lymphapheresis but exacerbation of disease activity developed at an average of 19 weeks. No significant untoward effects of the procedure were observed; occasional transfusions were required to compensate for the small, unavoidable erythrocyte loss.<\/jats:p>","DOI":"10.1002\/art.1780221002","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:10:24Z","timestamp":1171476624000},"page":"1055-1059","source":"Crossref","is-referenced-by-count":56,"title":["Lymphocyte depletion by continuous flow cell centrifugation in rheumatoid arthritis"],"prefix":"10.1002","volume":"22","author":[{"given":"Jacob","family":"Karsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Klippel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert B.","family":"Deisseroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Wayne","family":"Flye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197509112931101"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105758"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.1.40"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200614"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/217816a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1971.tb04383.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196611172752002"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1182\/blood.V39.2.163.163","article-title":"Leukapheresis therapy of chronic lymphocyte leukemia","volume":"39","author":"Curtis JE","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_10_2","first-page":"393","article-title":"Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis","volume":"37","author":"Ritchie DM","year":"1968","journal-title":"Q J Med"},{"key":"e_1_2_1_11_2","first-page":"39","article-title":"Articular index for the assessment of rheumatoid arthritis","volume":"4","author":"Camp AV","year":"1971","journal-title":"Orthopaedics"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080214"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-97-23681"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780221002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780221002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:54:47Z","timestamp":1700697287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780221002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1002\/art.1780221002"],"URL":"https:\/\/doi.org\/10.1002\/art.1780221002","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}