{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:26Z","timestamp":1761155006004},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9550,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clearance rate of isotopically labeled synthetic triclinic calcium pyrophosphate dihydrate (CPPD) crystals injected into rabbit joints was estimated by serial counting. Kinetic analysis using a four compartment model showed that half of the injected dose was cleared from 4 rabbit knee joints in 19.1 \u00b1 0.42 (SEM) days. Profound hypomagnesemia, produced in 2 rabbits with a low magnesium diet, did not affect the rate of crystal clearance detectably. Lavage of joints with solutions known to promote CPPD crystal solubility failed to remove detectable radioactivity. The previous finding of CPPD crystals in synovial phagocytes by electron microscopy, together with the finding of nuclide activity in the synovium and the failure to remove such activity by joint lavage, suggests that endocytosis by synovial cells is an important, effective mechanism controlling the synovial fluid concentration of crystals in patients with CPPD crystal deposition disease.<\/jats:p>","DOI":"10.1002\/art.1780221012","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:10:24Z","timestamp":1171476624000},"page":"1122-1131","source":"Crossref","is-referenced-by-count":25,"title":["Clearance of calcium pyrophosphate dihydrate crystals in vivo"],"prefix":"10.1002","volume":"22","author":[{"given":"Daniel J.","family":"Mccarty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220705"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-56-5-711"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220812"},{"key":"e_1_2_1_5_2","first-page":"331","article-title":"Pseudogout syndrome (articular chondrocalcinosis)","volume":"14","author":"McCarty DJ","year":"1964","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108239"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190116"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110308"},{"key":"e_1_2_1_9_2","first-page":"1099","article-title":"A study of crystal\u2010induced synovitis\u2014thirty\u2010three cases of calcification of the menisci of the knee joint","volume":"44","author":"Kariya M","year":"1970","journal-title":"J Lab Orthop Assoc"},{"key":"e_1_2_1_10_2","first-page":"518","article-title":"Elevated inorganic pyrophosphate concentration in synovial fluid in osteoarthritis and pseudogout","volume":"83","author":"Silcox DC","year":"1974","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90638-X"},{"key":"e_1_2_1_12_2","unstructured":"MilazzoSC HendersonDRF ClelandLG et al: Calcium pyrophosphate dihydrate crystal deposition disease and familial hypomagnesemia. Proceedings of the XIVth International Congress of Rheumatology San Francisco June1977 abstract #441"},{"key":"e_1_2_1_13_2","first-page":"283","article-title":"Condrocalcinosis e hipomagnesemia: un nueve sindrome","volume":"3","author":"Rapado A","year":"1976","journal-title":"Rev Esp Reum"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90481-7"},{"key":"e_1_2_1_15_2","unstructured":"CurdJ: Personal communication"},{"key":"e_1_2_1_16_2","first-page":"216","article-title":"Inorganic pyrophosphate concentration in the synovial fluid of arthritis patients","volume":"72","author":"McCarty DJ","year":"1971","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_17_2","first-page":"277","article-title":"Erythrocyte neutral inorganic pyrophosphatase in pseudogout","volume":"79","author":"McCarty DJ","year":"1972","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0021-9258(18)44989-7","article-title":"The effects of a magnesium\u2010deficient diet on the serum phosphatase activity in the albino rat","volume":"146","author":"Snyder FH","year":"1942","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/2071292b0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19760103"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-145-37854"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197557040-00013"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/jn\/76.1.90","article-title":"Effect of a magnesium\u2010deficient diet on magnesium metabolism in rabbits: a study with 28Mg","volume":"76","author":"Aikawa JK","year":"1962","journal-title":"J Nutrition"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(66)90159-4"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196901000-00003"},{"key":"e_1_2_1_26_2","first-page":"297","article-title":"Intracellular magnesium deficiency in man","volume":"20","author":"MacIntyre I","year":"1961","journal-title":"Clin Sci"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19620008"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780221012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780221012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:54:43Z","timestamp":1700697283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780221012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1002\/art.1780221012"],"URL":"https:\/\/doi.org\/10.1002\/art.1780221012","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}