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Because salicylates are the agents most commonly employed in treatment of osteoarthritis and because we recently showed that 10\u22123<\/jats:sup>M<\/jats:italic> sodium salicylate (i.e., approximately 20 mg%) suppresses proteoglycan synthesis in normal canine knee cartilage in vitro, we have studied the effects of this compound on osteoarthritic knee cartilage from dogs whose anterior cruciate ligament had been transected 9 weeks previously. The data indicated that the augmented synthesis of glycosaminoglycans in the degenerating cartilage was suppressed to a much greater degree by 10\u22123<\/jats:sup>M<\/jats:italic> sodium salicylate than the lower level of glycosaminoglycan synthesis in control cartilage from the contralateral knee of the same animal. Uptake of 14<\/jats:sup>C\u2010acetylsalicylic acid was increased about 35% in osteoarthritic cartilage, suggesting that the drug permeated it more readily than normal cartilage. The salicylate\u2010induced suppression of proteoglycan synthesis in the osteoarthritic cartilage was not accompanied by reversal of the defect in proteoglycan aggregation or by improvement in the (presumed) defect in proteoglycan\u2010collagen interaction in the matrix, as reflected by the abnormally high proportion of 35<\/jats:sup>S\u2010proteoglycans present in the culture medium.<\/jats:p>","DOI":"10.1002\/art.1780230114","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:41:01Z","timestamp":1171478461000},"page":"83-91","source":"Crossref","is-referenced-by-count":93,"title":["Marked suppression by salicylate of the augmented proteoglycan synthesis in osteoarthritic cartilage"],"prefix":"10.1002","volume":"23","author":[{"given":"Marshall J.","family":"Palmoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Colyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1016\/S0021-9258(18)62892-3","article-title":"Macromolecular models of protein polysaccharides from bovine nasal cartilage based on electron microscopic studies","volume":"245","author":"Rosenberg L","year":"1970","journal-title":"J Biol Chem"},{"key":"e_1_2_1_3_2","first-page":"131","volume-title":"Physico\u2010chemical properties of articular cartilage, Adult Articular Cartilage","author":"Maroudas A","year":"1973"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(70)90388-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(73)90093-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1016\/S0021-9258(19)42507-6","article-title":"Aggregation of cartilage proteoglycans. 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