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Association with the DRw4 antigen was found only in seropositive RA (61%, compared with 27% in normal controls; <jats:italic>P<\/jats:italic> &lt; 0.05, Fisher's exact test), whereas the antigen had a normal frequency in seronegative RA patients (27%). The serum concentrations of IgM and IgE immunoglobulins were significantly higher in seropositive than in seronegative RA patients (<jats:italic>P<\/jats:italic> &lt; 0.01, Mann\u2010Whitney test), whereas the concentrations of the other immunoglobulin classes and of the complement factors C3 and C4 did not show any significant differences.<\/jats:p>","DOI":"10.1002\/art.1780230307","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:06:16Z","timestamp":1171479976000},"page":"309-313","source":"Crossref","is-referenced-by-count":97,"title":["Hla antigens and rheumatoid arthritis association between hla\u2010drw4 positivity and igm rheumatoid factor production"],"prefix":"10.1002","volume":"23","author":[{"given":"Jan H.","family":"Dobloug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ystein","family":"F\u00f8rre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"K\u00e5ss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Thorsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1974.tb01289.x"},{"key":"e_1_2_1_3_2","first-page":"733","article-title":"Specificity of rheumatoid factors cross\u2010reacting with human and rabbit IgG","volume":"82","author":"Gaarder PI","year":"1974","journal-title":"Acta Pathol Microbiol Scand (B)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00435.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1979.tb02732.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(76)90094-5"},{"key":"e_1_2_1_7_2","series-title":"INSERM Symposium No. 8","first-page":"221","volume-title":"Distribution of HLA\u2010DR (human la\u2010like) antigens on human lymphoid cell subpopulations and their role in T lymphocyte cell\u2010interactions","author":"Thorsby E","year":"1978"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981602"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90963-2"},{"key":"e_1_2_1_10_2","first-page":"175","article-title":"1959 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_11_2","first-page":"616","article-title":"The human histocompatibility complex HLA: some recent developments","volume":"9","author":"Thorsby E","year":"1979","journal-title":"Transplant Proc"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01563899"},{"key":"e_1_2_1_13_2","volume-title":"BMDP, Biomedical Computer Programs","author":"Dixon WJ","year":"1975"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01575660"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200501"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1979.tb01137.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6148.1326"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91186-3"},{"key":"e_1_2_1_19_2","unstructured":"RyderLP AndersenE SvejgaardA:HLA and disease: third report from the HLA and disease registry. 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