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Patients in whom a favorable response to therapy was noted had more severe joint involvement at the start of therapy than did nonresponders. In general, patients who responded experienced considerable improvement. Duration of disease prior to gold therapy initiation and disease onset type were not related to the probability of favorable response. Incidence of adverse side effects was low. Gold has recently been approved by the Food and Drug Administration for use in children.<\/jats:p>","DOI":"10.1002\/art.1780230403","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:05:41Z","timestamp":1171479941000},"page":"404-411","source":"Crossref","is-referenced-by-count":55,"title":["Gold therapy in the management of juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"23","author":[{"suffix":"Jr.","given":"Earl J.","family":"Brewer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Barkley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"323","article-title":"Laurotherapie dans les rhumatismes chronique","volume":"53","author":"Forestier J","year":"1929","journal-title":"Bull Soc Med Hop Paris"},{"key":"e_1_2_1_3_2","first-page":"1132","article-title":"Die gunstige Beeinflussung schleichender Dauerinfekte durch Solganal","volume":"74","author":"Lande K","year":"1927","journal-title":"Munchen Med Wochenshr"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.4.294"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.4.301"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170108"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108660"},{"key":"e_1_2_1_8_2","first-page":"357","article-title":"Effects of a gold salt on lymphocyte responses","volume":"27","author":"Harth M","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.1.1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/iai.21.1.340-341.1978","article-title":"Inhibition of mycoplasma\u2010induced lymphocyte activation by sodium aurothiomalate","volume":"21","author":"Naot Y","year":"1978","journal-title":"Infect Immun"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01966611"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.120.5.1625","article-title":"Inhibition of the alternate pathway of complement by gold sodium thiomalate in vitro","volume":"120","author":"Burge JJ","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747809095647"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.28.5.541"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80102-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1957.3.issue-1-4.18"},{"key":"e_1_2_1_17_2","first-page":"105","article-title":"The toxicity of gold therapy in children suffering from rheumatoid arthritis","volume":"8","author":"Sairanen E","year":"1962","journal-title":"Ann Paediatr Fenn"},{"key":"e_1_2_1_18_2","first-page":"274","article-title":"The results of gold therapy in juvenile rheumatoid arthritis","volume":"10","author":"Sairanen E","year":"1963","journal-title":"Ann Paediatr Fenn"},{"key":"e_1_2_1_19_2","first-page":"205","volume-title":"Juvenile rheumatoid arthritis","author":"Brewer EJ","year":"1970"},{"key":"e_1_2_1_20_2","unstructured":"HansonV HicksR KornreichH:Gold therapy in the treatment of juvenile rheumatoid arthritis. 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