{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:10Z","timestamp":1762160590861},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":9385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood lymphocytes transformed significantly to denatured type I collagen in 22 of 38 patients with rheumatoid arthritis (58%), 1 of 9 patients with Reiter's disease (<jats:italic>P<\/jats:italic> &lt; 0.05), and 9 of 32 controls (28%) (<jats:italic>P<\/jats:italic> &lt; 0.01). Determination of HLA antigens revealed significant differences between 24 rheumatoid arthritis (RA) patients and a control population for HLA\u2010DRw4 (75% versus 23%). No correlation was observed between lymphocyte transformation to collagen and antibodies to collagen, rheumatoid factor, stage or duration of RA, or HLA antigens.<\/jats:p>","DOI":"10.1002\/art.1780230405","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:05:41Z","timestamp":1171479941000},"page":"424-432","source":"Crossref","is-referenced-by-count":38,"title":["Lymphocyte transformation to denatured type i collagen and b lymphocyte alloantigens in rheumatoid arthritis"],"prefix":"10.1002","volume":"23","author":[{"given":"J. S.","family":"Smolen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Menzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Scherak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kojer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kolarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. R.","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104224"},{"key":"e_1_2_1_3_2","first-page":"221","article-title":"Nuclear antigens and antinuclear antibodies: their role in joint inflammation","volume":"2","author":"Zvaifler NJ","year":"1975","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","first-page":"219","article-title":"Consideration of pathogenesis of rheumatoid arthritis as collagen autoimmunity","volume":"139","author":"Steffen C","year":"1970","journal-title":"Z Immunitaetsforsch Immunobiol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(74)90035-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.5.446"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190314"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210212"},{"key":"e_1_2_1_9_2","first-page":"265","volume-title":"The immunopathology of joint inflammation in rheumatoid arthritis, Advances in Immunology","author":"Zvaifler NJ","year":"1973"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196609292751307"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170508"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.5.431"},{"key":"e_1_2_1_13_2","first-page":"169","article-title":"Delayed hypersensitivity reactions to collagen in rats with adjuvant arthritis","volume":"141","author":"Steffen C","year":"1971","journal-title":"Z Immunitaetsforsch Immunobiol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808172990703"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210719"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90002-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108382"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981602"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6148.1326"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90280-5"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(78)90041-7"},{"key":"e_1_2_1_22_2","first-page":"137","article-title":"Criteria for diagnosis and classification of rheumatic diseases, Primer on the Rheumatic Diseases","volume":"224","year":"1973","journal-title":"JAMA"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00776a005"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1016\/S0021-9258(19)44716-9","article-title":"Collagen heterogeneity: high resolution separation of native [\u03b1,(I)]2a2 and [\u03b1(II)]3 and their component \u03b1\u2010chains","volume":"247","author":"Trelstadt RL","year":"1972","journal-title":"J Biol Chem"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4130.1200"},{"key":"e_1_2_1_27_2","first-page":"205","volume-title":"The collagen of joints, The Joints and Synovial Fluid","author":"Miller EJ","year":"1978"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90106-3"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(76)80073-5"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(62)90095-7"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90167-2"},{"key":"e_1_2_1_32_2","first-page":"70","article-title":"Lumphozytentransformation mit Mitogenen in serumfreiem und serumh\u00e4ltigem Medium bei Patienten mit chronischer Polyarthritis","volume":"90","author":"Smolen JS","year":"1978","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(73)90047-0"},{"key":"e_1_2_1_34_2","volume-title":"Statistics at Square One","author":"Swinscow TDV","year":"1976"},{"key":"e_1_2_1_35_2","first-page":"488","article-title":"HLA\u2010Ph\u00e4notypen\u2010, Gen\u2010 und Haplotypenfre\u2010quenz in der Wiener Bev\u00f6lkerung","volume":"87","author":"Mayr WR","year":"1975","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/262795a0"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.3.857"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108929"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(77)90168-5"},{"key":"e_1_2_1_40_2","first-page":"1","article-title":"Leukocyte migration inhibition with aggregated gamma globulin in patients with rheumatoid arthritis","volume":"15","author":"Brostoff J","year":"1973","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107648"},{"key":"e_1_2_1_42_2","first-page":"409","article-title":"Cellular immunity to autologous IgG in rheumatoid arthritis and rheumatoid like disorders","volume":"20","author":"Weisbart RH","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_43_2","first-page":"281","article-title":"Etude de la migration des leucocytes en presence d'immunoglobulines G non denaturees dans la polyarthrite rhumatoide","volume":"235","author":"Massoud A","year":"1976","journal-title":"Lyon Med"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1978.tb16817.x"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(76)90306-8"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000231352"},{"key":"e_1_2_1_47_2","first-page":"87","article-title":"Leukocyte migration inhibition with collagen type I and collagen type III in rheumatoid arthritis and degenerative joint disease","volume":"37","author":"Endler AT","year":"1978","journal-title":"Z Rheumatol"},{"key":"e_1_2_1_48_2","first-page":"369","article-title":"Cellular sensitivity to collagen in adjuvant arthritis (abstract)","volume":"25","author":"Trentham DE","year":"1977","journal-title":"Clin Res"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992202"},{"key":"e_1_2_1_50_2","first-page":"739","article-title":"The structural basis of cell\u2010mediated immunological reactions of collagen: reactivity of separated \u03b1\u2010chains of calf and rat collagen in cutaneous delayed hypersensitivity reactions","volume":"23","author":"Adelmann BC","year":"1972","journal-title":"Immunology"},{"key":"e_1_2_1_51_2","unstructured":"ScherakO SmolenJ MayrWR:Rheumatoid arthritis and B\u2010lymphocyte alloantigen HLA DRw4. J Rheumatol (in press)"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780230405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780230405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:27:42Z","timestamp":1700710062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780230405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,4]]}},"alternative-id":["10.1002\/art.1780230405"],"URL":"https:\/\/doi.org\/10.1002\/art.1780230405","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4]]}}}