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During 8 days in tissue culture, the synovial cells produced large amounts of collagenase and prostaglandin E2, but only low levels of both neurtral and acid proteinases. Sixty\u2010seven percent of the lymphocytes from the synovium were T cells; 19% were B cells. Attempts to identify agent\/antigen in the synovial cells were unsuccessful. Thus, the synovium of this patient, whose disease appears to be tick\u2010transmitted, resembles that of rheumatoid arthritis. This finding further supports the hypothesis that many possible agents, including infectious ones, trigger a common pathway in synovium, which leads to joint destruction.<\/jats:p>","DOI":"10.1002\/art.1780230511","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:04:36Z","timestamp":1171479876000},"page":"591-599","source":"Crossref","is-referenced-by-count":59,"title":["Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis"],"prefix":"10.1002","volume":"23","author":[{"given":"Allen C.","family":"Steere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance E.","family":"Brinckerhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Drinker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Edward D.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Malawista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112625"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112626"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-5-730"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200102"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-6-685"},{"key":"e_1_2_1_7_2","first-page":"353","article-title":"Lyme arthritis: related problems recently recognized in Connecticut","volume":"42","author":"Steere AC","year":"1978","journal-title":"Conn Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197907000-00001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-6-896"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.3.945"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210702"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2362.1975.tb02363.x","article-title":"Radioimmunoassay for prostaglandin F, E and E2 in human plasma","volume":"5","author":"Bray F","year":"1975","journal-title":"Eur J Clin Invest"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197509112931101"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-21-2-429"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.6.1728"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981602"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.870973"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109324"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220506"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197912203012502"},{"key":"e_1_2_1_22_2","first-page":"429","volume-title":"Pathology of rheumatoid arthritis and allied disorders, Arthritis and Allied Conditions: A Textbook of Rheumatology","author":"Sokoloff L","year":"1979"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.205952"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197705052961801"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(72)90249-5"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409122911105"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130109"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200302"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60169-4"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780070502"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-6-951"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-5-709"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-5-564"}],"container-title":["Arthritis &amp; 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