{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:10:54Z","timestamp":1700755854135},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9214,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1980,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By use of a hemolytic plaque assay, it has been determined that most cells secreting the clinically important (anti\u2010X) erythrocyte autoantibody of NZB mice are located in the bone marrow. There was evidence of excessive polyclonal B cell activation in NZB spleen but not in bone marrow, despite the role of marrow as the major source of erythrocyte autoantibody. These findings suggest that polyclonal activation of B cells within the marrow does not lead to erythrocyte autoantibody production. Small but significant numbers of anti\u2010erythrocyte autoantibody producing cells were detected in the bone marrow but not in the spleens of normal mice, indicating that tolerance to erythrocytes may be less absolute in the bone marrow than in the spleen, or that the bone marrow serves as a repository for autoantibody secreting cells generated elsewhere.<\/jats:p>","DOI":"10.1002\/art.1780230912","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T18:51:00Z","timestamp":1171479060000},"page":"1045-1048","source":"Crossref","is-referenced-by-count":8,"title":["Bone marrow as the major site of antierythrocyte autoantibody production in nzb mice"],"prefix":"10.1002","volume":"23","author":[{"given":"Philip L.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The agar plaque technique for recognizing antibody\u2010producing cells, Cell\u2010Bound Antibodies","author":"Jerne NK","year":"1963"},{"key":"e_1_2_1_3_2","first-page":"61","article-title":"Sites of antibody production in the guinea pig: the relationship between in vitro synthesis of anti\u2010ovalbumin and gamma globulin and distribution of antibody containing plasma cells","volume":"37","author":"Askonas BA","year":"1956","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/100.2.147"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60170-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230409"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.109.6.1386","article-title":"Immunoglobulin synthesis by human lymphoid tissues: normal bone marrow as a major site of IgG production","volume":"109","author":"McMillan R","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","first-page":"431","article-title":"Identification of derepressed autoimmunocompetent B lymphoid cells in NZB mice","volume":"16","author":"DeHeer DH","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.4049\/jimmunol.108.6.1615","article-title":"Antigenic specificity of anti\u2010erythrocyte autoantibody responses by NZB mice: identification and partial characterization of two erythrocyte surface autoantigens","volume":"108","author":"Linder E","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4049\/jimmunol.102.1.155","article-title":"Critical variables of the Jerne plaque technique as applied to rodent antibody\u2010forming systems responding to heterologous red cell antigens","volume":"102","author":"Hubner KF","year":"1969","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34264"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1968.215.2.353"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.4049\/jimmunol.119.5.1639","article-title":"Demonstration of activation of B lymphocytes in New Zealand black mice at birth by an immunoradiometric assay for murine IgM","volume":"119","author":"Moutsopoulos HM","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4049\/jimmunol.121.3.973","article-title":"Characterization of a B cell defect in the NZB mouse manifested by an increased ratio of surface IgM to IgD","volume":"121","author":"Cohen PL","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000313811"},{"key":"e_1_2_1_16_2","first-page":"247","article-title":"Antibody formation in mouse bone marrow. 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Evidence for the development of plaque forming cells in situ","volume":"26","author":"Benner R","year":"1974","journal-title":"Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108546"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90235-0"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780230912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780230912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:55:38Z","timestamp":1700754938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780230912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["10.1002\/art.1780230912"],"URL":"https:\/\/doi.org\/10.1002\/art.1780230912","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}