{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:20:25Z","timestamp":1759580425085},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9184,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1980,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paget's disease of bone is characterized by focal resorption of existing bone followed by the deposition of woven and lamellar bone in a characteristic pattern. Although bone turnover may be markedly increased, the coupling between formation and resorption is maintained. Metabolically there is increased efflux and influx of mineral ions in the involved areas. In addition, there is a parallel increase in resorption of matrix components, particularly collagen, with increased excretion of degradation products containing 4\u2010hydroxyproline, hydroxylysine, and its glycosides. A portion of the urinary 4\u2010hydroxyproline and hydroxylysine is in the form of peptides of approximately 5,000 daltons which appear to be related to collagen synthesis. Circulating levels of other organic matrix components are also increased such as procollagen fragments and the \u03b3\u2010carboxyglutamic acid\u2010bone protein. The increased levels of most of these metabolites return toward normal with specific therapy. The pattern of change suggests that bone resorption is decreased initially with therapy followed by a coupled decrease information.<\/jats:p>","DOI":"10.1002\/art.1780231004","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:12:36Z","timestamp":1171480356000},"page":"1087-1094","source":"Crossref","is-referenced-by-count":16,"title":["Skeletal metabolism in paget's disease of bone"],"prefix":"10.1002","volume":"23","author":[{"given":"Stephen M.","family":"Krane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-068702-2.50011-8"},{"key":"e_1_2_1_3_2","first-page":"24","article-title":"Paget's disease of bone","volume":"127","author":"Krane SM","year":"1977","journal-title":"Clin Orthop"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00005792-196405000-00004","article-title":"Paget's disease of bone: clinical and metabolic observations","volume":"43","author":"Nagant de Deuxchaisnes C","year":"1964","journal-title":"Medicine"},{"key":"e_1_2_1_5_2","first-page":"57","volume-title":"Skeletal remodeling and metabolic bone disease, Calcium Regulating Hormones","author":"Krane SM","year":"1975"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103340"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(73)90028-0"},{"key":"e_1_2_1_8_2","first-page":"261","article-title":"The clinical measurement of skeletal blood flow","volume":"50","author":"Wootton R","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_9_2","first-page":"55","article-title":"Skeletal scintimaging and radiography in the diagnosis and management of Paget's disease","volume":"127","author":"Wellman HN","year":"1977","journal-title":"Clin Orthop"},{"key":"e_1_2_1_10_2","first-page":"25","volume-title":"Composition, structure, and organization of bone and other mineralized tissues and the mechanism of calcification, Handbook of Physiology. 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