{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:55:50Z","timestamp":1774140950258,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010four sera from children with juvenile rheumatoid arthritis (JRA) were separated by gel filtration at pH 4.05. The serum and IgM and IgG\u2010containing fractions were analyzed for heterophile antibodies by subjecting them to a hemolytic assay in tubes with the target cell a 1% washed sheep erythrocyte (SRBC) or beef erythrocyte (BRBC) in suspension. Thirty\u2010three of 54 sera showed hemolytic antibody titers &gt;1:640 against SRBC alone and 4 of 54 had titers &gt;1:320 against SRBC and BRBC. All positive titers against SRBC and BRBC were associated with the IgM fraction. Differential absorption with SRBC, BRBC, and tissue sediment of homogenized guinea pig kidney revealed a Forssman specificity in 33 sera and Forssman and Hanganutziu\u2010Deicher specificity in 4. The presence of heterophile antibodies in JRA correlated with the presence of hidden rheumatoid factor. There was also an increased incidence in patients with positive antinuclear antibodies and in teenaged females with polyarticular disease.<\/jats:p>","DOI":"10.1002\/art.1780231106","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:10:11Z","timestamp":1171480211000},"page":"1262-1267","source":"Crossref","is-referenced-by-count":7,"title":["19S IgM forssman\u2010type heterophhile antibodies in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"23","author":[{"given":"Terry L.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"78","article-title":"Die Herstellung hochwertiger spezifischer Sch\u00e4fh\u00e4molysine ohne Verwendung von Schafblut","volume":"37","author":"Forssman J","year":"1911","journal-title":"Biochem Z"},{"key":"e_1_2_1_3_2","first-page":"201","article-title":"Heterophile antigens and antibodies in transplantation and tumors","volume":"7","author":"Milgrom F","year":"1975","journal-title":"Transplant Proc"},{"key":"e_1_2_1_4_2","first-page":"335","article-title":"Ueber blutgruppenspezifische Antik\u00f6rper und Antigene","volume":"40","author":"Schiff F","year":"1924","journal-title":"Immuno Forsch"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ajcp\/5.6.455","article-title":"Nature of heterophile antibodies in infectious mononucleosis","volume":"5","author":"Davidsohn I","year":"1935","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4049\/jimmunol.123.1.92","article-title":"Characterization of anti\u2010Forssman antibodies in human sera: their specificity and possible changes in patients with cancer","volume":"123","author":"Young WW","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","first-page":"239","article-title":"Ueber das Vorkommen heterophiler H\u00e4molysen in den Menschensera verschiedener Gruppen und ihr Verh\u00e4ltnis zu den Isoantik\u00f6rpern","volume":"59","author":"Fujioka N","year":"1928","journal-title":"Z Immunitaetsforsch"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/44.1.65"},{"key":"e_1_2_1_9_2","first-page":"841","article-title":"Heterophile phenomena in immunology","volume":"19","author":"Buchbinder L","year":"1935","journal-title":"Arch Pathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210604"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193201000-00010"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000232331"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.4.1018"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1429"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197403000-00006"},{"key":"e_1_2_1_16_2","first-page":"1457","article-title":"H\u00e9magglutinines h\u00e9t\u00e9rog\u00e9n\u00e9tiques apres injection de serum de cheval","volume":"91","author":"Hanganutziu M","year":"1929","journal-title":"C R Seanc Soc Biol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02176298"},{"key":"e_1_2_1_18_2","first-page":"122","article-title":"Heterophile antibodies in pathologic human sera resembling antibodies stimulated by foreign species sera","volume":"25","author":"Kasukawa R","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210810"},{"key":"e_1_2_1_20_2","first-page":"195","article-title":"Current proposed revision of JRA criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Section of the Arthritis Foundation","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090603"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.3.255"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210713"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.7.3023"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00435.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80699-9"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(197607\/08)19:4<711::AID-ART1780190409>3.0.CO;2-I"},{"key":"e_1_2_1_28_2","first-page":"12","volume-title":"Blood group and Forssman antigenic determinants shared between microbes and mammalian cells, Progress in Allergy","author":"Springer GF","year":"1971"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780231106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780231106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T07:14:29Z","timestamp":1700723669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780231106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1002\/art.1780231106"],"URL":"https:\/\/doi.org\/10.1002\/art.1780231106","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}