{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:33:22Z","timestamp":1770982402438,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,23]],"date-time":"2005-11-23T00:00:00Z","timestamp":1132704000000},"content-version":"vor","delay-in-days":9033,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunohistochemical studies were performed in synovial tissues from 40 patients with rheumatoid arthritis (RA), 9 with juvenile rheumatoid arthritis (JRA), 7 with psoriatic arthritis, and 4 with various rheumatic diseases. Overall synthesis of IgG\u2013 and\/or IgM\u2013rheumatoid factor (RF) was found in all patients with seropositive RA and JRA, in 75% of patients with seronegative RA, and in 1 patient with psoriatic arthritis. Agglutinator producing cells were found in 77% of the samples from seropositive RA and in 44% and 56% from seronegative RA and JRA patients, respectively. The percentage of IgG plasma cells synthesizing one or more of the 5 types of agglutinators studied was approximately 10% of plasma cells synthesizing IgG\u2013RF. Intercellular and intracellular immune complex deposits were also found in patients with seropositive and seronegative RA and JRA. These findings suggest that synthesis of agglutinators by synovial tissue plasma cells of RA and JRA patients is a distinct\u2014but definitely less prominent\u2014function than that of RF synthesis.<\/jats:p>","DOI":"10.1002\/art.1780240310","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:20:57Z","timestamp":1171480857000},"page":"510-519","source":"Crossref","is-referenced-by-count":35,"title":["Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and nonrheumatoid synovial tissues"],"prefix":"10.1002","volume":"24","author":[{"given":"Kurt","family":"Fehr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Velvart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Rauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margrit","family":"Kn\u00f6pfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Baici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathima","family":"Salgam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"B\u00f6ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.110.6.875"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1972.tb01813.x"},{"key":"e_1_2_1_4_2","series-title":"Ann NY Acad Sci","first-page":"88","author":"Natvig JB","year":"1975"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747209105005"},{"key":"e_1_2_1_6_2","first-page":"198","article-title":"Immunopathology of rheumatoid arthritis. I. The rheumatoid synovitis","volume":"2","author":"Nowoslawski A","year":"1967","journal-title":"Pathol Europ"},{"key":"e_1_2_1_7_2","first-page":"86","volume-title":"Proceedings of the International Symposium on Immune Complex Diseases","author":"Munthe E","year":"1970"},{"key":"e_1_2_1_8_2","first-page":"249","article-title":"Characterization of IgG complexes in eluates from rheumatoid tissue","volume":"8","author":"Munthe E","year":"1971","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","first-page":"889","article-title":"Evidence for immune complexes containing antibody to the pepsin site of IgG in rheumatoid synovial fluids","volume":"8","author":"Mellbye OJ","year":"1971","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200613"},{"key":"e_1_2_1_11_2","first-page":"375","volume-title":"Advances in Inflammation Research","author":"Fehr K","year":"1979"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.2.85"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747609099918"},{"key":"e_1_2_1_14_2","first-page":"95","article-title":"The induction of synovitis in the normal rabbit with Fab","volume":"54","author":"Rawson AJ","year":"1969","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4049\/jimmunol.105.4.973","article-title":"Degradation of immunoglobulin G by lysosomal acid protease","volume":"105","author":"Fehr K","year":"1970","journal-title":"J Immunol"},{"key":"e_1_2_1_17_2","first-page":"181","volume-title":"Proteinases in Mammalian Cells and Tissues","author":"Barrett AJ","year":"1977"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(76)90266-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972395"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0730119"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(60)90049-7"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200510"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(76)90177-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1980.tb00039.x"},{"key":"e_1_2_1_25_2","first-page":"457","article-title":"An immuno\u2010fluorescence procedure for detection of intracellular immunoglobulins","volume":"4","author":"Hijmans W","year":"1969","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"814","DOI":"10.4049\/jimmunol.107.3.814","article-title":"Exposure of hidden antigenic determinants in human IgG by digestion with spleen proteases","volume":"107","author":"Fehr K","year":"1971","journal-title":"J Immunol"},{"key":"e_1_2_1_27_2","first-page":"767","article-title":"An immunofluorescence mixed staining technique for the detection of IgG\u2010rheumatoid factor and IgG\u2010b\u03031c complexes in tissues","volume":"6","author":"Tursi A","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210307"},{"key":"e_1_2_1_29_2","first-page":"257","article-title":"Experimentally produced antibodies to the pepsin site of IgG due to untreated autologous IgG in immune complexes","volume":"7","author":"Mellbye OJ","year":"1970","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_30_2","first-page":"1373","article-title":"In vitro stimulation of lymphocytes by neutral proteinases from human polymorphonuclear leukocyte granules","volume":"106","author":"Bretz U","year":"1976","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_31_2","first-page":"422","article-title":"Immunofluorescence studies for immunoglobulins and complement C3 in synovial joint membranes in psoriatic arthritis","volume":"29","author":"Fyrand O","year":"1977","journal-title":"Clin Exp Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780240310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780240310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T20:03:39Z","timestamp":1700769819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780240310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1002\/art.1780240310"],"URL":"https:\/\/doi.org\/10.1002\/art.1780240310","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}