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Before ultracentrifugation all test sera showed apparent T\u03b3 cell specificity in the microcytotoxicity assay where rabbit complement was added. JRA and SLE sera produced much higher proportions of cell killing than normal controls. Ultracentrifugal clearing resulted in marked diminution in microcytoxicity of JRA and some SLE sera. However, a considerable proportion of lupus sera continued to show T cell subset cytotoxicity after ultracentrifugal clearing. No evidence for significant alteration of T\u03b3 resetting capacity was recorded when ultracentrifuge\u2010cleared test sera were preincubated with T cells prior to T\u03b3 EA rosette formation. Apparent T\u03b3 cytotoxic specificity in some uncleared JRA and SLE sera may relate to high molecular weight materials (IgM and immune complexes) present in such samples, whereas in others it relates to lymphocyte reactive antibody with subset reactivity.<\/jats:p>","DOI":"10.1002\/art.1780240403","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:19:53Z","timestamp":1171480793000},"page":"585-591","source":"Crossref","is-referenced-by-count":19,"title":["T\u03b3 cell subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera"],"prefix":"10.1002","volume":"24","author":[{"suffix":"Jr.","given":"R. C.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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