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This contrasts with idiopathic pulmonary fibrosis. Limited pepsin digestion released greater amounts of collagen (55%) than normal (16%), but the individual collagen chains were chemically indistinguishable. A reduced amount of the more stable collagen crosslink, hydroxylysinonorleucine, was observed which was consistent with the relatively greater degree of solubilization.<\/jats:p>","DOI":"10.1002\/art.1780240410","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:19:53Z","timestamp":1171480793000},"page":"625-631","source":"Crossref","is-referenced-by-count":19,"title":["Investigation of type i and type iii collagens of the lung in progressive systemic sclerosis"],"prefix":"10.1002","volume":"24","author":[{"given":"Jerome M.","family":"Seyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Rodnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.6.1351"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107827"},{"key":"e_1_2_1_4_2","first-page":"5","article-title":"Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma)","volume":"92","author":"Buckingham R","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(75)80138-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190510"},{"key":"e_1_2_1_7_2","unstructured":"UittoJ BauerEA EisenAZ:Scleroderma: increased biosynthesis of type I and type III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture. 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