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This enhancement could not be mediated through inhibition of prostaglandin biosynthesis since indomethacin had no effect on cytotoxic function and since the direct addition of PGE<jats:sub>2<\/jats:sub> to the cell cultures did not inhibit the expression of cytotoxicity. Likewise, salicylic acid (SA), which has no effect on prostaglandin biosynthesis, also enhanced monocyte cytotoxicity. Stimulation of monocyte\u2010mediated cytotoxicity resulting in more efficient antigen removal and thus decreasing antigen persistence may be an additional mechanism by which ASA, SA, and hydrocortisone modulate the destructive inflammatory response in rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780240604","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:15:23Z","timestamp":1171480523000},"page":"774-780","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacology of human spontaneous monocyte\u2010mediated cytotoxicity"],"prefix":"10.1002","volume":"24","author":[{"given":"E. S.","family":"Kleinerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Louie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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