{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:26:59Z","timestamp":1760264819889},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8946,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low molecular weight (LMW) IgM was measured in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and other rheumatic diseases. High levels were seen in RA, particularly in rheumatoid vasculitis and Felty's syndrome, and significant correlations occurred between LMW IgM and the rheumatoid factor (RF) level and other indices that reflected active or severe disease. LMW IgM\u2010RF, measured by radio\u2010immunoassay in those column fractions containing LMW IgM, correlated significantly with LMW IgM (<jats:italic>P<\/jats:italic> &lt; 0.005); preliminary experiments suggested that in some sera, a considerable proportion of the LMW IgM consisted of LMW IgM\u2010RF. We conclude that LMW IgM and LMW IgM\u2010RF may have important implications in the immunopathogenesis of RA and other rheumatic diseases.<\/jats:p>","DOI":"10.1002\/art.1780240607","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:15:23Z","timestamp":1171480523000},"page":"795-802","source":"Crossref","is-referenced-by-count":21,"title":["Low molecular weight IgM in rheumatoid arthritis and other rheumatic diseases"],"prefix":"10.1002","volume":"24","author":[{"given":"Peter J.","family":"Roberts\u2010Thomson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Wernick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Ziff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.125.5.893"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.3.601"},{"key":"e_1_2_1_4_2","first-page":"683","article-title":"Quantification and distribution of chicken immunoglobulins IgA, IgM and IgG in serum and secretions","volume":"27","author":"Lebacq\u2010Verheyden AM","year":"1974","journal-title":"Immunology"},{"key":"e_1_2_1_5_2","first-page":"194","article-title":"Low molecular weight IgM in human sera","volume":"73","author":"Bush ST","year":"1969","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_6_2","first-page":"143","article-title":"Occurrence of slowly sedimenting components with m\u0308 chain antigenicity in normal adult and cord serum","volume":"126","author":"Starita\u2010Geribaldi M","year":"1975","journal-title":"Ann Immunol (Inst Pasteur)"},{"key":"e_1_2_1_7_2","first-page":"831","article-title":"Low molecular weight IgM in sera of patients with rheumatoid arthritis","volume":"11","author":"LoSpalluto J","year":"1968","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4049\/jimmunol.115.1.216","article-title":"Naturally occurring low molecular weight IgM in patients with rheumatoid arthritis, systemic lupus erythematosus and macroglobulinaemia:purification and immunological studies","volume":"115","author":"Harris\u2010Dangkul V","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","first-page":"641","article-title":"Slowly sedimenting serum components reacting with anti\u2010IgM sera","volume":"13","author":"Klein F","year":"1967","journal-title":"Immunology"},{"key":"e_1_2_1_10_2","first-page":"291","article-title":"Low molecular weight IgM in the serum and cerebrospinal fluid of patients infected with Trypanosoma gambiense","volume":"143","author":"Masseyeff R","year":"1972","journal-title":"Immun Forsch Bd"},{"key":"e_1_2_1_11_2","first-page":"153","article-title":"Low molecular weight (7S) IgM and free light chains in the sera of patients with the tropical splenomegaly syndrome","volume":"28","author":"Fakunle Y","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197207000-00002"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230317"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1973.tb02057.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4049\/jimmunol.102.2.496","article-title":"Molecular heterogenicity of immunoglobulin\u2010M (\u03b3M\u2010globulin)","volume":"102","author":"Solomon A","year":"1969","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106214"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140403"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170312"},{"key":"e_1_2_1_19_2","first-page":"537","article-title":"Effect of complement fixation by 7S IgM","volume":"16","author":"Caldwell JR","year":"1973","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0021-9258(18)91849-1","article-title":"Studies on antigen binding activity of macroglobulin antibody subunits and their enzymatic fragments","volume":"244","author":"Chavin SI","year":"1969","journal-title":"J Biol Chem"},{"key":"e_1_2_1_21_2","unstructured":"WernickRM LoSpallutoJJ ZiffM:Solid phase radioimmunoassay of the measurement of IgG and IgM rheumatoid factors in absolute quantities. Submitted for publication"},{"key":"e_1_2_1_22_2","first-page":"175","article-title":"Revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_23_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus","volume":"21","author":"Cohen AS","year":"1979","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_24_2","first-page":"45","article-title":"Circulating immune complexes in IgA deficiency","volume":"38","author":"Kwitko AO","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108399"},{"key":"e_1_2_1_26_2","first-page":"408","article-title":"A nephelometric study of the reaction of monoclonal rheumatoid factor with heat aggregated gammaglobulin and sera from patients with immune complex diseases","volume":"37","author":"Roberts\u2010Thomson PJ","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.4.349"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90042-9"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.5.438"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(61)90064-X"},{"key":"e_1_2_1_31_2","first-page":"426","article-title":"Low molecular IgM in rheumatoid synovial fluid","volume":"15","author":"Anderson\u2010Imbert A","year":"1972","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105127"},{"key":"e_1_2_1_33_2","first-page":"204","article-title":"Monomeric (7S) IgM in chronic liver disease","volume":"38","author":"Fakunle YM","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105625"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210304"},{"key":"e_1_2_1_36_2","first-page":"381","article-title":"Immunoglobulin class of antibodies to cow's milk casein in infant sera and evidence for low molecular weight IgM antibodies","volume":"15","author":"Hunter A","year":"1968","journal-title":"Immunology"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.4049\/jimmunol.100.6.1296","article-title":"Comparison of certain properties of naturally occurring low molecular weight \u03b3M and the \u03b3M monomer derived by reduction and alkylation of 19S \u03b3M","volume":"100","author":"Swedlund HA","year":"1968","journal-title":"J Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780240607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780240607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:57:09Z","timestamp":1700762229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780240607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,6]]}},"alternative-id":["10.1002\/art.1780240607"],"URL":"https:\/\/doi.org\/10.1002\/art.1780240607","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,6]]}}}