{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:52Z","timestamp":1760188852184},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8642,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The autologous and allogeneic mixed lymphocyte reactions (MLR), observed when peripheral blood mononuclear cells from 20 patients with progressive systemic sclerosis were used, were compared with those of age\u2010, sex\u2010, and race\u2010matched normal controls. Such cells were separated by gradient centrifugation of sheep red blood cell (E) rosettes into stimulator (E\u2010 or non\u2010T cell) and responder (E+ or T cell) populations. The autologous MLR of both the progressive systemic sclerosis and normal peripheral blood mononuclear cells varied widely but there was no statistical difference between the means of each group. In the allogeneic MLR, proliferation between progressive systemic sclerosis non\u2010T cells and normal T cells was significantly less than that of normal non\u2010T cells and progressive systemic sclerosis T cells (<jats:italic>P<\/jats:italic> = 0.001). A decreased autologous MLR, while noted with other autoimmune diseases, was lacking in progressive systemic sclerosis. This suggests a different defect. The differences in the allogeneic MLR also suggest that either progressive systemic sclerosis non\u2010T cells were poor stimulators or T cells associated with this disease were better responders when compared with similarly prepared cell populations from normal individuals. The MLR differences could have also resulted from compositional subset alterations or the sharing of a common antigen. HLA\u2014DR5 was found in 9 of the 17 white patients with progressive systemic sclerosis. Although these individuals were evenly distributed as low, medium, and high responders, this finding showed that some progressive systemic sclerosis non\u2010T cells shared a common antigen.<\/jats:p>","DOI":"10.1002\/art.1780250405","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:43:38Z","timestamp":1171482218000},"page":"390-395","source":"Crossref","is-referenced-by-count":14,"title":["Autologous and allogeneic mixed lymphocyte reactions in progressive systemic sclerosis"],"prefix":"10.1002","volume":"25","author":[{"given":"Jane H.","family":"Morse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy S.","family":"Bodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110502"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_1_4_2","first-page":"744","article-title":"Immune complexes (IC) in progressive systemic sclerosis (PSS)","volume":"23","author":"Siebold TR","year":"1980","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_5_2","first-page":"301","article-title":"Immune complexes in progressive systemic sclerosis and mixed connective tissue disease","volume":"7","author":"Cunningham P","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(75)80096-7"},{"key":"e_1_2_1_7_2","first-page":"336","article-title":"Circulating T and B lymphocytes in progressive systemic sclerosis","volume":"2","author":"de Jesus DG","year":"1975","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb00855.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190507"},{"key":"e_1_2_1_10_2","first-page":"233","article-title":"The relationship of defective cell\u2010mediated immunity to visceral disease in systemic sclerosis","volume":"28","author":"Hughes P","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_11_2","first-page":"342","article-title":"Subpopulations of human T lymphocytes. 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