{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:05:42Z","timestamp":1789913142621,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8642,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, we found interferon in the sera of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and Sj\u00f6gren's syndrome. In this study, we surveyed a variety of other immunologically mediated diseases. We did not find interferon in the sera of patients with Wegener's granulomatosis, sarcoidosis, infectious mononucleosis, minimal change nephritis, kidney transplants, myasthenia gravis, or uveitis, but we did find this protein in the sera of patients with active systemic and cutaneous vasculitis. Attempts to characterize the interferon in the sera of patients with systemic lupus erythematosus and vasculitis revealed that antibody to alpha (leukocyte) interferon, but not to beta (fibroblast) interferon, partially or completely neutralized the antiviral activity. The failure of antibody to alpha interferon to completely neutralize the antiviral activity in certain specimens and the lability of the antiviral activity in some specimens to pH 2.0 treatment both suggest that more than one type of interferon was present.<\/jats:p>","DOI":"10.1002\/art.1780250406","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:43:38Z","timestamp":1171482218000},"page":"396-400","source":"Crossref","is-referenced-by-count":125,"title":["Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis"],"prefix":"10.1002","volume":"25","author":[{"given":"John J.","family":"Hooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cupps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralampos M.","family":"Moutsopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Fauci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abner Louis","family":"Notkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/286110a0"},{"key":"e_1_2_1_3_2","first-page":"443","volume-title":"The comparative biology of immune and classical interferon, Biology of Lymphokines","author":"Epstein LB","year":"1979"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.164.3886.1415"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.115.5.1191","article-title":"Production of interferon by immune lymphocytes exposed to herpes simplex virus\u2010antibody complexes","volume":"115","author":"Fujibayaski T","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3681.310"},{"key":"e_1_2_1_7_2","first-page":"20","article-title":"Synthesis of interferon in human lymphocytes stimulated \u201cin vitro\u201d by antilymphocytic serum","author":"Falcoff E","year":"1972","journal-title":"Rev Europ Etudes Clin et Biol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197907053010102"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb20603.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-660"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197311000-00002"},{"key":"e_1_2_1_12_2","first-page":"554","article-title":"Inhibition of polyclonal B\u2010cell activation by suppressor monocytes in patients with sarcoidosis","volume":"32","author":"Katz P","year":"1978","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.123.5.2095","article-title":"Emergence of suppressor cells of immunoglobulin synthesis during acute Epstein\u2010Barr virus\u2010induced infectious mononucleosis","volume":"123","author":"Haynes BF","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","first-page":"36","article-title":"Interferon: identification and assay","volume":"18","author":"Hooks JJ","year":"1980","journal-title":"Lab Manag"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.4049\/jimmunol.123.3.1382","article-title":"Demonstration of circulating immune complexes in Siogren's syndrome","volume":"123","author":"Lawley TJ","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(80)90204-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.3.637"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-4-587"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/284593a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.3.633"},{"key":"e_1_2_1_21_2","first-page":"373","article-title":"The effect of exogenous inteferon: acceleration of autoimmune and renal disease in (NZB\/W) F1 mice","volume":"40","author":"Adam C","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1979.tb47128.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/287401a0"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780250406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780250406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:29:05Z","timestamp":1700767745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780250406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1002\/art.1780250406"],"URL":"https:\/\/doi.org\/10.1002\/art.1780250406","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}