{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:33:25Z","timestamp":1770982405460,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relative frequencies of IgM antilgG autoantibody (rheumatoid factor) producing cells induced by the polyclonal B cell activator Epstein\u2010Barr virus were measured in peripheral blood lymphocyte cultures of normal children and patients with juvenile rheumatoid arthritis. The frequencies of rheumatoid factor precursor B cells in normal children were lower than adults, but higher than neonates. The frequency increased with the age of the donor. In seronegative children with the systemic\u2010onset or pauclarticular\u2010onset types of juvenile rheumatoid arthritis, the number of IgM antiIgG inducible B cells was not significantly different (<jats:italic>P<\/jats:italic>&gt;0.05) from age\u2010matched controls. Patients with seropositive juvenile rheumatoid arthritis or seropositive adult rheumatoid arthritis had significantly higher IgM antiIgG precursor cell frequencies than age\u2010matched normal subjects (<jats:italic>P<\/jats:italic>&lt;0.01 and <jats:italic>P<\/jats:italic>&lt;0.02, respectively). In contrast, the patients with seronegative polyarticular\u2010onset juvenile rheumatoid arthritis had an average precursor frequency significantly lower than normal age\u2010matched controls (<jats:italic>P<\/jats:italic>&lt;0.05), analogous to results previously noted in adult seronegative rheumatoid arthritis. Thus, both children and adults with seronegative polyarticular rheumatoid arthritis had a deficiency in B cells that produce IgM antiIgG and that are induced by Epstein\u2010Barr virus. This distinguished them from seropositive juvenile rheumatoid arthritis and rheumatoid arthritis patients, normal subjects, and patients with the pauciarticular\u2010onset and systemic\u2010onset types of seronegative juvenile rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780250808","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:58:39Z","timestamp":1171483119000},"page":"959-965","source":"Crossref","is-referenced-by-count":19,"title":["Frequencies of epstein\u2010barr virus\u2014inducible IgM anti\u2010IgG B lymphocytes in normal children and children with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"25","author":[{"given":"Sherman","family":"Fong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"John J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine D.","family":"Tsoukas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis A.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1429"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.4049\/jimmunol.126.3.910","article-title":"Age\u2010associated changes in Epstein\u2010Barr virus\u2010induced human lymphocyte autoantibody responses","volume":"126","author":"Fong S","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109927"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240603"},{"key":"e_1_2_1_6_2","first-page":"184","article-title":"Three subtypes of juvenile rheumatoid arthritis: correlations of age at onset, sex, and serological factors","volume":"20","author":"Hanson V","year":"1977","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198010000-00010"},{"key":"e_1_2_1_8_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_9_2","first-page":"665","article-title":"Clq binding in serum in juvenile rheumatoid arthritis","volume":"7","author":"Miller JJ","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4049\/jimmunol.116.1.232","article-title":"Detection of immune complexes in unheated sera by a modified 125I\u2010Clq binding test","volume":"116","author":"Zubler RH","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210810"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.1.64"},{"issue":"97","key":"e_1_2_1_13_2","first-page":"77","article-title":"Separaton of leukocytes from blood and bone marrow","volume":"21","author":"Boyum A","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020412"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(74)90043-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90207-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780120204"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780010602"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(56)90134-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241008"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210713"},{"key":"e_1_2_1_22_2","first-page":"101","article-title":"Immune complexes in juvenile rheumatoid arthritis","volume":"24","author":"Moore TL","year":"1981","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_23_2","first-page":"121","volume-title":"Juvenile Rheumatoid Arthritis","author":"Kredich DW","year":"1979"},{"key":"e_1_2_1_24_2","unstructured":"H\u00f6yeraalHM ForreO DoblougJH ThorsbyE KassE:HLA\u2010antigens in juvenile rheumatoid arthritis patients: association between immunoglobulin M rheumatoid factor production and the HLA\u2010DR4 antigen (abstract). 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