{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:21Z","timestamp":1761512361670},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Group I pepsinogens were measured by radioimmunoassay in the sera of 93 patients with rheumatic diseases and 99 controls. Patients with rheumatoid arthritis and systemic lupus erythematosus had levels of pepsinogen I similar to controls, whereas patients with Sj\u00f6gren's syndrome had levels significantly lower than either controls (<jats:italic>P<\/jats:italic>&lt;0.001) or patients with rheumatic diseases not associated with sicca syndrome (<jats:italic>P<\/jats:italic>&lt;0.001). The concentrations of serum pepsinogen I were lower in patients with sicca syndrome alone than in those with sicca syndrome associated with some other connective tissue disease (<jats:italic>P<\/jats:italic>&lt;0.05). In patients with Sj\u00f6gren's syndrome, a negative correlation was found between serum concentrations of \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin and pepsinogen I (r = \u22120.46, <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p>","DOI":"10.1002\/art.1780250905","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:56:39Z","timestamp":1171482999000},"page":"1059-1063","source":"Crossref","is-referenced-by-count":10,"title":["Serum pepsinogen i in rheumatic diseases. reduced levels in sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"C. Peter J.","family":"Maury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VESA","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Maija","family":"Teppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapani","family":"Helve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Wegelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0016-5085(19)32321-2","article-title":"A study of the relationship between serum group I pepsinogen levels and gastric acid secretion","volume":"69","author":"Samloff IM","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32639-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308427"},{"key":"e_1_2_1_5_2","first-page":"175","article-title":"Revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1968","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_6_2","unstructured":"MauryCPJ TeppoA\u2010M WegeliusO: Relationship between urinary sialyl\u2010oligosaccharides serum C\u2010reactive proteins and amyloid A protein in rheumatoid arthritis and systemic lupus erythematosus.Ann Rheum Dis(in press)"},{"key":"e_1_2_1_7_2","first-page":"643","article-title":"Preliminary criteria for the classification of systemic lupus erythematosus","volume":"21","author":"Cohen AS","year":"1971","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(74)80035-1"},{"key":"e_1_2_1_10_2","first-page":"700","article-title":"A radioimmunoassay for group I pepsinogens in human serum","volume":"18","author":"R\u00e4s\u00e4nen V","year":"1980","journal-title":"J Clin Chem Clin Biochem"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209081057"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308327"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-4-537"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1947.tb13134.x"},{"key":"e_1_2_1_15_2","first-page":"930","article-title":"Gastric biopsy in patients with Sj\u00f6gren's syndrome","volume":"16","author":"von Jabavy M","year":"1961","journal-title":"Z Med Lab Diagn"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92785-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.54.1.31"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1970.16.issue-1-4.22"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1966.11800612"},{"key":"e_1_2_1_20_2","first-page":"123","article-title":"Family behaviour of chronic gastritis","volume":"13","author":"Varis K","year":"1981","journal-title":"Ann Clin Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)91110-0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190214"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4049\/jimmunol.119.3.932","article-title":"Purification of an acidic nuclear protein antigen and demonstration of its antibodies in subsets of patients with sicca syndrome","volume":"119","author":"Akizuki M","year":"1977","journal-title":"J Immunol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197910043011405"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197512112932404"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.3.246"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.1.14"}],"container-title":["Arthritis &amp; 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