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Breeding studies demonstrated that susceptibility was a dominant or codominant trait. A positive association between the severity of arthritis and the development of chronic inflammation in multiple tissues was also observed. In strains that were relatively resistant to arthritis, chronic inflammation was generally limited to the spleen. Since translocation of the poorly degradable and phlogogenic streptococcal cell walls to the synovium and other tissues appears to initiate inflammation, these studies suggested that susceptibility might be the result of a defect in host mechanisms limiting cell wall dissemination.<\/jats:p>","DOI":"10.1002\/art.1780250906","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:56:39Z","timestamp":1171482999000},"page":"1064-1072","source":"Crossref","is-referenced-by-count":128,"title":["STRAIN and sex variation in the susceptibility to streptococcal CELL WALL\u2013INDUCED POLYARTHRITIS IN THE RAT"],"prefix":"10.1002","volume":"25","author":[{"given":"Ronald L.","family":"Wilder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary B.","family":"Calandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Julian","family":"Garvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl T.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"308","volume-title":"Arthritis in animals, Arthritis and Allied Diseases","author":"Pearson CM","year":"1979"},{"key":"e_1_2_1_3_2","first-page":"147","volume-title":"Infection and Immunology in the Rheumatic Disease","author":"Catterall RD","year":"1976"},{"key":"e_1_2_1_4_2","first-page":"1203","volume-title":"Textbook of Rheumatology","author":"Morgan 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