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Sixteen children with juvenile dermatomyositis, including 7 with subcutaneous calcifications, were studied to determine if abnormal synthesis or turnover of Gla\u2010containing proteins occurred. All study children had increased excretion of the amino acid that was greater than that of age\u2010and sex\u2010matched controls. Patients who had juvenile dermatomyositis with calcifications had a 3\u2010fold increase in Gla excretion, and those without calcinosis had a 2\u2010fold increase. Five other children with various connective tissue disorders and subcutaneous calcification had 2\u2010fold increased Gla excretion. Decreased excretion of this amino acid was associated with salicylate therapy (80 mg\/kg\/24 hours). The data suggest an abnormal turnover of Gla\u2010containing proteins in juvenile dermatomyositis. Metabolism of these proteins may be involved in the pathophysiology of soft\u2010tissue calcification in children.<\/jats:p>","DOI":"10.1002\/art.1780250910","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:56:39Z","timestamp":1171482999000},"page":"1094-1100","source":"Crossref","is-referenced-by-count":44,"title":["GAMMA\u2010carboxyglutamate excretion and calcinosis in juvenile dermatomyositis"],"prefix":"10.1002","volume":"25","author":[{"given":"Jane B.","family":"Lian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caren M.","family":"Gundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAYMOND E. 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