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Fortythree (47%) had abnormal results on two or more of these tests, but only 17 (18%) had normal results by all three assays. Computer\u2010assisted analysis of immune complex results and extensive clinical and laboratory data compiled on these patients revealed that the patients with abnormal Raji cell assays more often had diffuse scleroderma, tendon friction rubs, and positive serum antinuclear antibody tests than did patients with negative results on Raji cell assays. Individuals with immune complexes detected by C1q binding had evidence of pulmonary involvement and positive serum rheumatoid factor more frequently than did patients whose C1q tests were negative.<\/jats:p>","DOI":"10.1002\/art.1780251004","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:46:47Z","timestamp":1171482407000},"page":"1167-1173","source":"Crossref","is-referenced-by-count":44,"title":["Immune complexes in progressive systemic sclerosis (scleroderma)"],"prefix":"10.1002","volume":"25","author":[{"given":"James R.","family":"Seibold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Winkelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald P.","family":"Rodnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(75)90017-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-5-788"},{"key":"e_1_2_1_4_2","first-page":"762","volume-title":"Arthritis and Allied Conditions","author":"Rodnan GP","year":"1979"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220512"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220815"},{"key":"e_1_2_1_7_2","first-page":"301","article-title":"Immune complexes in progressive systemic sclerosis and mixed connective tissue disease","volume":"7","author":"Cunningham PH","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2340\/0001555559421426","article-title":"Circulating immune complexes in lupus erythematosus, scleroderma and dermatomyositis","volume":"59","author":"S\u00f8lling J","year":"1979","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250463"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108257"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4049\/jimmunol.116.1.232","article-title":"Detection of immune complexes in unheated sera by a modified 125I\u2010C1q binding test: effect of heating on the binding of C1q by immune complexes and application of the test to systemic lupus erythematosus","volume":"116","author":"Zubler RH","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.3.396"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109863"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109396"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(75)80096-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-4-394"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-4-753"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/136.2.216"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220501"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220507"},{"key":"e_1_2_1_22_2","first-page":"1","article-title":"A collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum","volume":"1","author":"Lambert PH","year":"1978","journal-title":"J Lab Clin Immunol"},{"key":"e_1_2_1_23_2","unstructured":"ZilberfarbJL DavisJS AndrewsBS: Enhancement of C1q binding by IgM rheumatoid factor (Igm\u2010RF).Clin Res(in press)"},{"key":"e_1_2_1_24_2","first-page":"405","article-title":"Interpretation of the Raji cell assay in sera containing anti\u2010nuclear antibodies and immune complexes","volume":"44","author":"Horsfall AC","year":"1981","journal-title":"Clin Exp Immunol"}],"container-title":["Arthritis &amp; 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