{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:36Z","timestamp":1760188836166},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8459,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010one patients with progressive systemic sclerosis were studied for the presence of immune complexes by the fluid\u2010 and solid\u2010phase C1q binding, C1 activation, and the fluid\u2010phase conglutinin assays. Complement activation and autoantibodies were also studied. Immune complexes were detected in only 6 patients (15%); activation of complement was found in 5 others. The clinical and serologic features of patients with complexes were compared with those in whom complexes were not identified. No significant difference was found with respect to serology. Organ involvement was generally more frequent in the group with immune complexes, but the difference was statistically significant only with respect to lung involvement. The present data suggest that, although complement\u2010fixing immune complexes are infrequently detected in progressive systemic sclerosis, they may play a role in the pathogenesis of lung lesions associated with the disease.<\/jats:p>","DOI":"10.1002\/art.1780251005","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:46:47Z","timestamp":1171482407000},"page":"1174-1179","source":"Crossref","is-referenced-by-count":27,"title":["Circulating immune complexes in patients with progressive systemic 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