{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:15:43Z","timestamp":1770059743851,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8428,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Utah Cooperating Clinics","award":["(NIH AM-62218)"],"award-info":[{"award-number":["(NIH AM-62218)"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AM-25543"],"award-info":[{"award-number":["AM-25543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AM-28568"],"award-info":[{"award-number":["AM-28568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune female New Zealand Black\/New Zealand White mice were treated with frentizole, an experimental immunosuppressive drug. Three groups of \u201cyoung,\u201d 8\u2010week\u2010old mice received high\u2010dose frentizole (80\u201384 mg\/kg\/day), low\u2010dose frentizole (8 mg\/kg\/day), or no drug (controls); these mice were followed until spontaneous death. Three groups of \u201cold,\u201d 24\u2010week\u2010old mice with established lupus\u2010like disease were treated with high or low doses of frentizole. Old control mice received no drug. After 12 weeks of therapy, surviving old mice were killed. Beneficial therapeutic response was achieved when high\u2010dose treatment was started at an early age; antiDNA values were suppressed, and longevity was prolonged significantly. Frentizole did not arrest the progression of renal disease in old mice. Glomerulonephritis and vasculitis were the most common causes of death in young and old animals. Twenty\u2010nine percent of young, high\u2010dose\u2010treated mice died with neoplasms. Large glomerular deposits of IgG, IgM, and C3 were present in renal tissue from treated and control mice. Peripheral lymphocyte counts and mitogenic responses of spleen cells were not changed by treatment. The efficacy of frentizole in a murine model of lupus supports its usefulness as an immunoregulatory drug.<\/jats:p>","DOI":"10.1002\/art.1780251104","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:46:36Z","timestamp":1171482396000},"page":"1291-1297","source":"Crossref","is-referenced-by-count":17,"title":["Prolonged lifespans in female nzb\/nzw mice treated with the experimental immunoregulatory drug frentizole"],"prefix":"10.1002","volume":"25","author":[{"given":"Sara Ellen","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Solsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Schnitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00306a010"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00306a011"},{"key":"e_1_2_1_4_2","unstructured":"Lilly Research Laboratories: Information for Clinical Investigators: Frentizole. Indianapolis Lilly Research Laboratories 1977"},{"key":"e_1_2_1_5_2","first-page":"619","article-title":"Augmented incidence of neoplasia in NZB\/NZW mice treated with long\u2010term cyclophosphamide","volume":"82","author":"Walker SE","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1978.102"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180312"},{"key":"e_1_2_1_8_2","first-page":"932","article-title":"Palmerston North mice:a new animal model of systemic lupus erythematosus","volume":"92","author":"Walker SE","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_9_2","first-page":"104","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231208"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231209"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780221204"},{"key":"e_1_2_1_13_2","first-page":"333","article-title":"Studies on frentizole:a novel immunosuppressive agent (abstract)","volume":"35","author":"Stone RL","year":"1976","journal-title":"Fed Proc"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231211"},{"key":"e_1_2_1_15_2","first-page":"601","article-title":"Frentizole therapy of thrombocytopenia in systemic lupus erythematosus and refractory idiopathic thrombocytopenic purpura","volume":"55","author":"O'sDuffy JD","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/iai.15.1.145-148.1977","article-title":"Frentizole, a novel immunosuppressive, and azathioprine:their comparative effects on host resistance to Pseudomonas aeruginosa, Candida albicans, Herpes simplex virus, and influenza (Ann Arbor) virus","volume":"15","author":"Scheetz ME","year":"1977","journal-title":"Infect Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780251104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780251104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780251104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T22:47:56Z","timestamp":1700693276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780251104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1982,11]]}},"alternative-id":["10.1002\/art.1780251104"],"URL":"https:\/\/doi.org\/10.1002\/art.1780251104","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,11]]}}}