{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:59:54Z","timestamp":1773079194545,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circadian variations in myoglobin levels were determined in 18 normal volunteers and in 10 patients with active polymyositis. In all the controls and in 9 of the 10 patients, serum myoglobin concentrations were highest at 9 <jats:sc>AM<\/jats:sc>, fell significantly during the day to reach a nadir between 6 and 12 <jats:sc>PM<\/jats:sc>, remained constant until midnight, and then rose again at 3 <jats:sc>AM<\/jats:sc>. The percent differences between the highest and lowest values ranged from 21\u201366%. This pattern was observed in both untreated patients and patients receiving 6\u2010methyl\u2010prednisolone, which was given either in a single dose at 8 <jats:sc>AM<\/jats:sc> or in divided doses (8 <jats:sc>AM<\/jats:sc> and 8 <jats:sc>PM<\/jats:sc>). These data demonstrate that the time of sample collection must be taken into account when myoglobin levels are used as a marker of muscle damage.<\/jats:p>","DOI":"10.1002\/art.1780251205","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:44:06Z","timestamp":1171482246000},"page":"1419-1424","source":"Crossref","is-referenced-by-count":16,"title":["Circadian variations of serum myoglobin levels in normal subjects and patients with polymyositis"],"prefix":"10.1002","volume":"25","author":[{"given":"Stefano","family":"Bombardieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Clerico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrezia","family":"Riente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia Del","family":"Chicca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Vitali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.237.14.1448"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200811"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(78)90206-5"},{"key":"e_1_2_1_5_2","first-page":"165","article-title":"\u2026And now myoglobin?","volume":"20","author":"Strauss HW","year":"1979","journal-title":"J Nucl Med"},{"key":"e_1_2_1_6_2","first-page":"149","article-title":"Serum myoglobin and \u201ccardiac\u201d specific isoenzymes in a case of polymyositis","volume":"23","author":"Bombardieri S","year":"1979","journal-title":"J Nucl Med All Sci"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_8_2","first-page":"147","article-title":"Radioimmunoassay of acute myocardial infarction markers (myoglobin, creatine kinase MB and lactate dehydrogenase H4)","volume":"22","author":"Zucchelli GC","year":"1978","journal-title":"J Nucl Med All Sci"},{"key":"e_1_2_1_9_2","first-page":"169","article-title":"Radioimmunoassay of circulating human myoglobin","volume":"22","author":"Malvano R","year":"1978","journal-title":"J Nucl Med All Sci"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1330529"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.139.6.644"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197211022871810"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(69)90009-0"},{"key":"e_1_2_1_14_2","first-page":"87","article-title":"Circadian, seasonal and substrain variation of enzymes in man (LDH\u2010isoenzymes) and rats (adenylate kinase, aldolase, CKP and LDH)","volume":"6","author":"Chemnitz G","year":"1979","journal-title":"Chronobiologia"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/clinchem\/23.1.69","article-title":"A radioimmunoassay for human serum myoglobin: method development and normal values","volume":"23","author":"Rosano TG","year":"1977","journal-title":"Clin Chem"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1093\/clinchem\/26.13.1864","article-title":"Age\u2010, sex\u2010, and race\u2010related differences in myoglobin concentrations in the serum of healthy persons","volume":"26","author":"Chen IW","year":"1980","journal-title":"Clin Chem"},{"key":"e_1_2_1_17_2","first-page":"341","article-title":"Radioimmunoassay for human myoglobin: methods and results in patients with skeletal\u2010muscle or myocardial disorders","volume":"92","author":"Miyoshi I","year":"1978","journal-title":"J Lab Clin Med"}],"container-title":["Arthritis &amp; 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