{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:38:54Z","timestamp":1791157134760,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T00:00:00Z","timestamp":1133136000000},"content-version":"vor","delay-in-days":8398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1982,12]]},"abstract":"Abstract<\/jats:title>Patients with systemic lupus erythematosus (SLE) were previously reported to have a high prevalence of circulating DNA in association with systemic vasculitis. The present study was designed to determine whether circulating DNA also characterizes forms of systemic arterial inflammation other than those associated with SLE. A specific counterimmunoelectrophoresis assay capable of detecting 20\u201350 ng\/ml of doublestranded DNA (dsDNA) in plasma was used. Of a total of 16 patients studied, 15 (94%) had circulating DNA. Similarly, 89% of the 47 plasmas from vasculitis patients contained DNA. In each of the 3 control groups, which consisted of normal individuals, patients with nonvasculitic systemic inflammation, and patients receiving high dose corticosteroid and\/or cytostatic agents, no more than 8% had plasma DNA. This difference was significant with P<\/jats:italic> < 0.001. Relevance of this observation to etiologic, pathogenetic, and clinical considerations in the systemic arteritides is discussed. It is suggested that clinical detection of circulating plasma DNA may be useful for the diagnosis and management of systemic polyarteritis nodosa and related syndromes.<\/jats:p>","DOI":"10.1002\/art.1780251206","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:44:06Z","timestamp":1171482246000},"page":"1425-1430","source":"Crossref","is-referenced-by-count":10,"title":["Circulating dna in polyarteritis nodosa and related syndromes"],"prefix":"10.1002","volume":"25","author":[{"given":"Charles R.","family":"Steinman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90789-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108118"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160108"},{"key":"e_1_2_1_5_2","first-page":"883","volume-title":"Polyarteritis nodosa and other types of vasculitis, Textbook of the Rheumatic Diseases","author":"Scott JT","year":"1978"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140211"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90872-5"},{"key":"e_1_2_1_8_2","first-page":"847","volume-title":"Miscellaneous and uncommon rheumatic conditions, Textbook of the Rheumatic Diseases","author":"Barnes CG","year":"1978"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","unstructured":"SteinmanCR:Detection and semiquantitation of DNA by counterimmunoelectrophoresis (CIE) Methods in Enzymology. 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