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To further define the prognostic value of this autoantibody, 27 patients, who were identified as having anticentromere antibody by screening antinuclear antibody tests using HEp\u20102 cell substrates, were followed clinically and serologically for 2 years. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. When compared with other patients who exhibit speckled or nucleolar antinuclear antibody patterns, those with anticentromere antibody had significantly less major organ system involvement.<\/jats:p>","DOI":"10.1002\/art.1780260101","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T19:56:37Z","timestamp":1171482997000},"page":"1-7","source":"Crossref","is-referenced-by-count":85,"title":["Anticentromere antibody"],"prefix":"10.1002","volume":"26","author":[{"given":"Gale Anne","family":"Mccarty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Bembe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Franc A.","family":"Barada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"430","article-title":"Profile of antinuclear antibodies in progressive systemic sclerosis (abstract)","volume":"18","author":"Tan EM","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_2","first-page":"640","article-title":"Complexity of antinuclear antibodies in scleroderma (abstract)","volume":"22","author":"Moroi Y","year":"1979","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1627"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0140-6736(63)92920-9","article-title":"Antinuclear and precipitating autoantibodies in progressive systemic sclerosis (scleroderma)","volume":"2","author":"Beck JS","year":"1963","journal-title":"Lancet"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110502"},{"key":"e_1_2_1_7_2","first-page":"111","article-title":"Antinuclear antibodies: their significance in scleroderma","volume":"46","author":"Jordon RE","year":"1971","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12492668"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/50.6.683"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90462-3"},{"key":"e_1_2_1_12_2","first-page":"S85","article-title":"Clinical correlations and favorable prognosis in patients with anticentromere antibody (abstract)","volume":"24","author":"McCarty GA","year":"1981","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.5.465"},{"key":"e_1_2_1_15_2","first-page":"339","article-title":"Characterization and comparison of commercially available antinuclear antibody kits using single pattern index sera","volume":"7","author":"McCarty GA","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","first-page":"172","volume-title":"Immunofluorescent Detection of Auto\u2010immune Diseases","author":"Cavalarro JJ","year":"1976"},{"key":"e_1_2_1_17_2","volume-title":"The Antinuclear Antibody Syllabus: Contemporary Techniques and Clinical Applications to Connective Tissue","author":"McCarty GA","year":"1981"},{"key":"e_1_2_1_18_2","first-page":"141","volume-title":"The use of white blood cell cultures in studying genetic and metabolic disease, Birth Defects Original Articles Series VII (i)","author":"Danes BS","year":"1971"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197611182952101"},{"key":"e_1_2_1_20_2","first-page":"800","article-title":"Relationship of nuclear staining patterns with precipitating antibodies in systemic lupus erythematosus","volume":"70","author":"Tan EM","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.131.5.639"},{"key":"e_1_2_1_22_2","first-page":"423","article-title":"Progressive systemic sclerosis\u2010CREST syndrome: observations on natural history and late complications in 90 patients (abstract)","volume":"18","author":"Rodnan GP","year":"1975","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_23_2","unstructured":"CattogioLJ MaddisonPJ MartinMRF SkinnerRP:Clinical and serologic correlations in progressive systemic sclerosis (abstract 0492). 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